Welcome! Click here to login or here to register.
 |
|||||||||||||||||||
|
|||||||||||||||||||
 |
|||||||||||||||||||
Gtf2h2 |
Protein FULL name:
general transcription factor II H, polypeptide 2 [Mus musculus].
Gtf2h2 (Mus musculus) is product of expression of Gtf2h2 gene.
FUNCTION: Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C- terminus is required for a successful escape of RNAP II form the promoter (By similarity).
SUBUNIT: One of the 6 subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor. Interacts with XPB, XPD, GTF2H1 and GTF2H3 (By similarity).
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Belongs to the GTF2H2 family.
SIMILARITY: Contains 1 VWFA domain.
| NCBI GenPept GI number(s): |
31981225 |
| Species: | Mus musculus |
Links to other databases:
| Database | ID | Link |
| Uniprot | Q9JIB4 |
Q9JIB4 |
| PFAM: | - |
Q9JIB4 (Link - using uniprot id) |
| InterPro: | - |
Q9JIB4 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MDEEPERTKRWEGGYERTWEILKEDETGSLKATIEDILFKAKRKRVFEHH GQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNP ISQIGIIVTKSKRAEKLTELSGNPRKHITSLKKAVDMTCHGEPSLYNSLS MAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYDLIKTLKTAKIRVSVIG LSAEVRVCTVLARETGGTYHVILDETHYKELLAHHVSPLPASSSSECSLI RMGFPQHTIASLSDQDAKPSFSMAHLDNNSTEPGLTLGGYFCPQCRAKYC ELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEISLEEYKGERFCYGCQ GELKDQHVYVCTVCQNVFCVDCDVFVHDSLHCCPGCIHKIPTPSGI |
Gtf2h2 (Mus musculus) belongs to following protein families:
References:
| Title | Authors | Journal |
| Genomic sequence analysis of the mouse Naip gene array. | Endrizzi MG, Hadinoto V, Growney JD, Miller W, Dietrich WF | Genome Res Aug. 1, 2000 |
Last modification of this entry: Oct. 6, 2010.
Add your own comment!
There is no comment yet.
|
|
|
|