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Clk2 |
Protein FULL name:
CDC-like kinase 2 [Mus musculus].
Clk2 (Mus musculus) is product of expression of Clk2 gene.
FUNCTION: Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SUBCELLULAR LOCATION: Nucleus (By similarity).
PTM: Autophosphorylates on all three types of residues.
SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.
SIMILARITY: Contains 1 protein kinase domain.
| NCBI GenPept GI number(s): |
6671764 |
| Species: | Mus musculus |
Links to other databases:
| Database | ID | Link |
| Uniprot | O35491 |
O35491 |
| PFAM: | - |
O35491 (Link - using uniprot id) |
| InterPro: | - |
O35491 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MPHPRRYHSSERGSRGSYHEHYQSRKHKRRRSRSWSSSSDRTRRRRREDS YHVRSRSSYDDHSSDRRLYDRRYCGSYRRNDYSRDRGEAYYDTDFRQSYE YHRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSHSSRRAKSVEDDAEGHL IYHVGDWLQERYEIVSTLGEGTSGRVVQCVDHRRGGTRVALKIIKNVEKY KEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTF DFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNS DYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPE VILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPVP SRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEDHHQ LFDLIENMLEYEPAKRLTLGEALQHPFFACLRTEPPNTKLWDSSRDISR |
Clk2 (Mus musculus) belongs to following protein families:
References:
| Title | Authors | Journal |
| Characterization and comparison of four serine- and arginine-rich (SR) protein kinases. | Nayler O, Stamm S, Ullrich A | Biochem J Sept. 15, 1997 |
Last modification of this entry: Oct. 6, 2010.
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