Protein FULL name:
cell division protein kinase 7 [Mus musculus].
Cdk7 (Mus musculus) is product of expression of
FUNCTION: Cyclin-dependent kinases (CDKs) are activated by the
binding to a cyclin and mediate the progression through the cell
cycle. Each different complex controls a specific transition
between two subsequent phases in the cell cycle. CDK7 is the
catalytic subunit of the CDK-activating kinase (CAK) complex, a
serine-threonine kinase. CAK activates the cyclin-associated
kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation.
CAK complexed to the core-TFIIH basal transcription factor
activates RNA polymerase II by serine phosphorylation of the
repetitive C-terminus domain (CTD) of its large subunit (POLR2A),
allowing its escape from the promoter and elongation of the
transcripts. Involved in cell cycle control and in RNA
transcription by RNA polymerase II. Its expression and activity
are constant throughout the cell cycle.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CATALYTIC ACTIVITY: ATP + [DNA-directed RNA polymerase] = ADP +
[DNA-directed RNA polymerase] phosphate.
ENZYME REGULATION: Phosphorylation at Thr-170 is required for
enzymatic activity (By similarity).
SUBUNIT: Associates primarily with cyclin H and MAT1 to form the
CAK complex. CAK can further associate with the core-TFIIH to form
the TFIIH basal transcription factor. Interacts with PUF60 (By
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Belongs to the protein kinase superfamily. CMGC
Ser/Thr protein kinase family. CDC2/CDKX subfamily.
SIMILARITY: Contains 1 protein kinase domain.
Links to other databases:
Cdk7 (Mus musculus) belongs to following protein families:
[Identification of new protein kinase genes, similar to kinases of the cdc2 family and expressed in murine hematopoietic stem cells]
||Ershler MA, Nagorskaia TV, Fisser IaV, Beliavskii AV
Dokl Akad Nauk
Jan. 1, 1992
An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain.
||Gilardi-Hebenstreit P, Nieto MA, Frain M, Mattei MG, Chestier A, Wilkinson DG, Charnay P
Dec. 1, 1992
Novel CDC2-related protein kinases produced in murine hematopoietic stem cells.
||Ershler M, Nagorskaya TV, Visser JW, Belyavsky AV
Jan. 28, 1993
Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase.
||Matsuoka M, Kato JY, Fisher RP, Morgan DO, Sherr CJ
Mol Cell Biol
Nov. 1, 1994
Sequence of the cDNA encoding murine CRK4 protein kinase.
||Stepanova LYu, Ershler MA, Belyavsky AV
Nov. 18, 1994
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
||Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J
Oct. 1, 2004
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
||Zanivan S, Gnad F, Wickstrom SA, Geiger T, Macek B, Cox J, Fassler R, Mann M
J Proteome Res
Dec. 1, 2008
Last modification of this entry: Oct. 6, 2010.
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