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Lig1 |
Protein FULL name:
DNA ligase 1 [Mus musculus].
Lig1 (Mus musculus) is product of expression of Lig1 gene.
FUNCTION: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
COFACTOR: Magnesium (By similarity).
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
| NCBI GenPept GI number(s): |
133892807 |
| Species: | Mus musculus |
Links to other databases:
| Database | ID | Link |
| Uniprot | P37913 |
P37913 |
| PFAM: | - |
P37913 (Link - using uniprot id) |
| InterPro: | - |
P37913 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MRKKEQERKGETSAANMQRSIMSFFQPTKEGKAKKPEKETPSSIREKEPP PKVALKERNQVVPESDSPVKRTGRKVAQVLSCEGEDEDEAPGTPKVQKPV SDSEQSSPPSPDTCPENSPVFNCSSPMDISPSGFPKRRTARKQLPKRTIQ DTLEEQNEDKTKTAKKRKKEEETPKESLAEAEDVKQKEEKEGDQLIVPSE PTKSPESVTLTKTENIPVCKAGVKLKPQEEEQSKPPARGAKTLSSFFTPR KPAVKTEVKQEESGTLRKEETKGTLDPANYNPSKNNYHPIEDACWKHGQK VPFLAVARTFEKIEEVSARLKMVETLSNLLRSVVALSPPDLLPVLYLSLN RLGPPQQGLELGVGDGVLLKAVAQATGRQLESIRAEVAEKGDVGLVAENS RSTQRLMLPPPPLTISGVFTKFCDIARLTGSASMAKKMDIIKGLFVACRH SEARYIARSLSGRLRLGLAEQSVLAALAQAVSLTPPGQEFPTAVVDAGKG KTAEARKMWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSP GVPLKPMLAHPTRGVSEVLKRFEEVDFTCEYKYDGQRAQIHVLEGGEVKI FSRNQEDNTGKYPDIISRIPKIKHPSVTSFILDTEAVAWDREKKQIQPFQ VLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLVRQPLSRRRQLLRENF VETEGEFVFTTSLDTKDTEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIA KRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLAAYDEE SEELQAICKLGTGFSDEELEEHHQSLQALVLPTPRPYVRIDGAVAPDHWL DPSIVWEVKCADLSLSPIYPAARGLVDKEKGISLRFPRFIRVRKDKQPEQ ATTSNQVASLYRKQSQIQNQQSSDLDSDVEDY |
Lig1 (Mus musculus) belongs to following protein families:
References:
| Title | Authors | Journal |
| Cloning and sequence analysis of a cDNA coding for the murine DNA ligase I enzyme. | Savini E, Biamonti G, Ciarrocchi G, Montecucco A | Gene July 8, 1994 |
| Comparison between cDNA clones encoding murine DNA ligase I. | Jessop JK, Melton DW | Gene July 28, 1995 |
| Large-scale phosphorylation analysis of mouse liver. | Villen J, Beausoleil SA, Gerber SA, Gygi SP | Proc Natl Acad Sci U S A Feb. 1, 2007 |
| The phagosomal proteome in interferon-gamma-activated macrophages. | Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P | Immunity Feb. 16, 2009 |
| Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. | Sweet SM, Bailey CM, Cunningham DL, Heath JK, Cooper HJ | Mol Cell Proteomics May 1, 2009 |
Last modification of this entry: Oct. 6, 2010.
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