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Tel1p |
Protein FULL name:
Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene
Tel1p (Saccharomyces cerevisiae) is product of expression of TEL1 gene.
Keywords:
FUNCTION: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited by the MRX-complex to sites of DNA lesions immediately after damage to initiate non- homologous end-joining (NHEJ). Subsequently displaced by the RPA complex in a reaction probably involving the SAE2 protein. Phosphorylates MRE11 and XRS2, 2 subunits of the MRX-complex. The phosphorylation of MRE11 is a feedback response from the checkpoint signaling pathway. Phosphorylates RAD9, CHK1 and RAD53, leading to the activation of the CHK1 and RAD23 kinases involved in the DNA damage response cascade. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Phosphorylates also SLX4 and RTT107 which are involved in genome stability. Required for the control of telomere length and genome stability.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SUBUNIT: Interacts with XRS2 and associates with DNA double-strand breaks.
INTERACTION: Q02979:GDE1; NbExp=1; IntAct=EBI-19099, EBI-31287;
SUBCELLULAR LOCATION: Nucleus. Telomere. Note=Localizes to nuclear DNA repair foci in response to DNA double strand breaks.
SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
SIMILARITY: Contains 1 FAT domain.
SIMILARITY: Contains 1 FATC domain.
SIMILARITY: Contains 1 PI3K/PI4K domain.
| NCBI GenPept GI number(s): |
6319383 |
| Species: | Saccharomyces cerevisiae |
Links to other databases:
| Database | ID | Link |
| Uniprot | P38110 |
P38110 |
| PFAM: | - |
P38110 (Link - using uniprot id) |
| InterPro: | - |
P38110 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
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MEDHGIVETLNFLSSTKIKERNNALDELTTILKEDPERIPTKALSTTAEA LVELLASEHTKYCDLLRNLTVSTTNKLSLSENRLSTISYVLRLFVEKSCE RFKVKTLKLLLAVVPELMVKDGSKSLLDAVSVHLSFALDALIKSDPFKLK FMIHQWISLVDKICEYFQSQMKLSMVDKTLTNFISILLNLLALDTVGIFQ VTRTITWTVIDFLRLSKKENGNTRLIMSLINQLILKCHCFSVIDTLMLIK EAWSYNLTIGCTSNELVQDQLSLFDVMSSELMNHKLPYMIGQENYVEELR SESLVSLYREYILLRLSNYKPQLFTVNHVEFSYIRGSRDKNSWFALPDFR LRDRGGRSVWLKILGITKSLLTYFALNRKNENYSLLFKRRKCDSDIPSIL RISDDMDTFLIHLLEENSSHEFEVLGLQLCSFYGTLQDFTKSFAEQLKEL LFSKFEKIQCFNWVCFSFIPLLSQKECELSNGDMARLFKVCLPLVKSNES CQLSCLLLANSIKFSKQLLSDEKTINQIYDLYELSDILGPILVTNESFML WGYLQYVGKDFQSMNGISSADRIFEWLKSKWNQLRGTDAKQDQFCNFISW LGNKYDPENPFNDKKGEGANPVSLCWDESHKIWQHFQEQREFLLGVKPEE KSECFNTPFFNLPKVSLDLTRYNEILYRLLENIESDAFSSPLQKFTWVAK LIQIVDNLCGDSTFSEFIAAYKRTTLITIPQLSFDSQNSYQSFFEEVLSI RTINVDHLVLDKINMKEIVNDFIRMQKNKSQTGTSAINYFEASSEDTTQN NSPYTIGGRFQKPLHSTIDKAVRAYLWSSRNKSISERLVAILEFSDCVST DVFISYLGTVCQWLKQAIGEKSSYNKILEEFTEVLGEKLLCNHYSSSNQA MLLLTSYIEAIRPQWLSYPEQPLNSDCNDILDWIISRFEDNSFTGVAPTV NLSMLLLSLLQNHDLSHGSIRGGKQRVFATFIKCLQKLDSSNIINIMNSI SSYMAQVSYKNQSIIFYEIKSLFGPPQQSIEKSAFYSLAMSMLSLVSYPS LVFSLEDMMTYSGFNHTRAFIQQALNKITVAFRYQNLTELFEYCKFDLIM YWFNRTKVPTSKLEKEWDISLFGFADIHEFLGRYFVEISAIYFSQGFNQK WILDMLHAITGNGDAYLVDNSYYLCIPLAFISGGVNELIFDILPQISGKT TVKYHKKYRLLMLKWIIRFTDLGSLTELRSTVEKLFPTSYLSPYLFENSS VSMRYQYPLHIPLALGATLVQTQFAHEKNNTHEFKLLFLSVITDLEKTST YIGKLRCARELKYLFVLYENVLVKSSTLNFIIIRLSKFLIDTQIHDEVIT IFSSLLNLADKNTFEIEPSLPNLFCKIFIYLRENKQLSPSFQQAIKLLEH RDLIKIKTWKYFLDAIFGNIVQDDIYENTELLDASDCGVDDVVLVSLLFS YARRPVASKIGCSLSKAAAINILKHHVPKEYLSKNFKLWFAALSRRILQQ EVQRERSTNFNNEVHLKNFEMVFRHPEQPHMIYQRISTFNKEAELYDSTE VFFISECILTYLVGYSIGNSESEFCFRDNIMNENKDKVAPLDKDVLNAIY PLANNFGMESFICDTYLSVNEPYNCWLSKFARSLIHQISFNIPPIVCLYP LCKGSTAFCELVLTDLFFLSTTYDPKSCLNWSNRIFTQIAMLLHVKDSEI KLKMLFNVIKMIRMGSRCKERNCLRIYSSLDLQEICQISLKIKEFKFGYL LFEEMNMPNIREMNINTLQKIYECINDGDFLAGLPVPHSIEGVLNSINRI DSDTWKRFLFNNADFDANYTTSLEEEKESLIKATEDSGFYGLTSLLESRL SGSSDVYKWNLELGDWKLLTPKVVDSKAKGLYYAIKNLPQDVGFAEKSLE KSLLTIFDSRQHFISQTEWMDTLNAIIEFIKIAAIPQDVTSFPQTLMSIM KADKERLNTIDFYDHKTTLKSRHTLMNVLSRNSLDENVKCSKYLRLGSII QLANYVQLAIANGAPQDALRNATLMSKTVKNIAKLYDDPSVVSQIEKLAS FTSANALWESREYKAPVMIMRDLLAQNEKNISESILYDDFKLLINVPMDQ IKARLVKWSSESRLEPAAAIYEKIIVNWDINVEDHESCSDVFYTLGSFLD EQAQKLRSNGEIEDREHRSYTGKSTLKALELIYKNTKLPENERKDAKRHY NRVLLQYNRDSEVLKALLLQKEKFLWHALHFYLNTLVFSNRYDNDIIDKF CGLWFENDDNSKINQLLYKEIGTIPSWKFLPWVNQIASKISMEENEFQKP LQLTMKRLLYKLPYDSLYSVMSILLYEKQSNKDTNISQKIQAVKKILLEL QGYDRGAFAKKYLLPVQEFCEMSVELANLKFVQNTKTLRLANLKIGQYWL KQLNMEKLPLPTSNFTVKSSADGRKARPYIVSVNETVGITTTGLSLPKIV TFNISDGTTQKALMKGSNDDLRQDAIMEQVFQQVNKVLQNDKVLRNLDLG IRTYKVVPLGPKAGIIEFVANSTSLHQILSKLHTNDKITFDQARKGMKAV QTKSNEERLKAYLKITNEIKPQLRNFFFDSFPDPLDWFEAKKTYTKGVAA SSIVGYILGLGDRHLNNILLDCSTGEPIHIDLGIAFDQGKLLPIPELVPF RLTRDIVDGFGVTGVDGLFRRSCERVYAVLRKDYVKVMCVLNILKWDPLY SWVMSPVKKYEHLFEEEHEITNFDNVSKFISNNDRNENQESYRALKGVEE KLMGNGLSVESSVQDLIQQATDPSNLSVIYMGWSPFY |
Tel1p (Saccharomyces cerevisiae) belongs to following protein families:
References:
Last modification of this entry: Oct. 6, 2010.
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