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Apn2p |
Protein FULL name:
apurinic/apyrimidinic (AP) lyase 2
Protein SHORT name:
APN2, ETH1
Apn2p (Saccharomyces cerevisiae) is product of expression of APN2 gene.
Apn2p is involved in:
BER in Saccharomyces cerevisiae
- Strand scission by APN1/APN2 complex in Saccharomyces cerevisiae
- 3' terminal unsaturated sugar removal in Saccharomyces cerevisiae
Keywords:
FUNCTION: DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA.
CATALYTIC ACTIVITY: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
SUBCELLULAR LOCATION: Nucleus.
MISCELLANEOUS: Present with 414 molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the DNA repair enzymes AP/exoA family.
| NCBI GenPept GI number(s): |
6319452 |
| Species: | Saccharomyces cerevisiae |
Links to other databases:
| Database | ID | Link |
| Uniprot | P38207 |
P38207 |
| PFAM: | - |
P38207 (Link - using uniprot id) |
| InterPro: | - |
P38207 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MSSSENTLLDGKSENTIRFLTFNVNGIRTFFHYQPFSQMNQSLRSVFDFF RADIITFQELKTEKLSISKWGRVDGFYSFISIPQTRKGYSGVGCWIRIPE KNHPLYHALQVVKAEEGITGYLTIKNGKHSAISYRNDVNQGIGGYDSLDP DLDEKSALELDSEGRCVMVELACGIVIISVYCPANSNSSEEGEMFRLRFL KVLLRRVRNLDKIGKKIVLMGDVNVCRDLIDSADTLEQFSIPITDPMGGT KLEAQYRDKAIQFIINPDTPHRRIFNQILADSLLPDASKRGILIDTTRLI QTRNRLKMYTVWNMLKNLRPSNYGSRIDFILVSLKLERCIKAADILPDIL GSDHCPVYSDLDILDDRIEPGTTQVPIPKFEARYKYNLRNHNVLEMFAKK DTNKESNKQKYCVSKVMNTKKNSNIKNKSLDSFFQKVNGEKDDRIKESSE IPQQAKKRISTPKLNFKDVFGKPPLCRHGEESMLKTSKTSANPGRKFWIC KRSRGDSNNTESSCGFFQWV |
Apn2p (Saccharomyces cerevisiae) is able to recognize following damages:
Apn2p (Saccharomyces cerevisiae) belongs to following protein families:
References:
| Title | Authors | Journal |
| Complete DNA sequence of yeast chromosome II. | Feldmann H, Aigle M, Aljinovic G, Andre B, Baclet MC, Barthe C, Baur A, Becam AM, Biteau N, Boles E, et al. | EMBO J Dec. 15, 1994 |
| Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites. | Johnson RE, Torres-Ramos CA, Izumi T, Mitra S, Prakash S, Prakash L | Genes Dev Oct. 1, 1998 |
| Apurinic endonuclease activity of yeast Apn2 protein. | Unk I, Haracska L, Johnson RE, Prakash S, Prakash L | J Biol Chem July 21, 2000 |
| Global analysis of protein expression in yeast. | Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS | Nature Oct. 16, 2003 |
Last modification of this entry: Oct. 16, 2010.
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