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Msh4p |
Msh4p is involved in:
HRR in Saccharomyces cerevisiae
Keywords:
FUNCTION: Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis.
SUBUNIT: Heterooligomer of MSH4 and MSH5.
INTERACTION: Q06032:CST9; NbExp=1; IntAct=EBI-11371, EBI-30044; Q12175:MSH5; NbExp=2; IntAct=EBI-11371, EBI-11377;
MISCELLANEOUS: Two distinct classes of crossovers have been demonstrated in budding yeast. Class I is MSH4/MSH5 dependent and exhibits crossover interference. Class II is MUS81/MMS4 dependent and exhibits no interference.
SIMILARITY: Belongs to the DNA mismatch repair mutS family.
| NCBI GenPept GI number(s): |
14318519 |
| Species: | Saccharomyces cerevisiae |
Links to other databases:
| Database | ID | Link |
| Uniprot | P40965 |
P40965 |
| PFAM: | - |
P40965 (Link - using uniprot id) |
| InterPro: | - |
P40965 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MSESNLSSFISTNYFNLRSAANSSNSISKPSTKKSIRNQKSPTNISSWAL KKKTLQIAETTWENNEKDSTHSHYLMTGSMASRTATSLSRYSTNASLLGP SIDCVLCCIYEVPRDISTRIGLCIINCNTGQMYLSDFMDSQIYIRVVHKL QIYQPTEILIPSSSLAPTVSKLATMIKFNVAETVKIEEGSRKCFNSQDGL AAITKYLMDDTKKDLKIEEIIDKTFALCAASAAISYMEEIISKSSRNLNA FRKLRIQFEGTENTMLIDSKTVRGLELVENKLDKNGISLWKFLDTTSTKM GQRSLRNSILQPLTDRGSIEMRLEALEELKANDDLLQKLRLEMKSLPDLD KLFSRLLCINHSAIKPDQRINYVLLLKETLQSVKSLKDALNDQLIQSRLI SETKKIFNNDAIMEIEKLINSCINEDCVWASSAIQLLNQRSYAVKSDSNG LLDVSRQIYKEVKEEFFREVEDLTAKNKINLDHNYDSARGFYLRIKRQEF TDDVATLPDVFISRTIKKNYIECTTLNIIKKNARLKEVMEEILLLSEETV DELLDKIATHISELFMIAEAVAILDLVCSFTYNLKENNYTIPIFTNNLLI RDSRHPLLEKVLKNFVPNTISSTKHSSSLQIITGCNMSGKSVYLKQVALI CIMAQMGSGIPALYGSFPVFKRLHARVCNDSMELTSSNFGFEMKEMAYFL DDINTETLLILDELGRGSSIADGFCVSLAVTEHLLRTEATVFLSTHFQDI PKIMSKKPAVSHLHMDAVLLNDNSVKMNYQLTQKSVAIENSGIRVVKKIF NPDIIAEAYNIHSLLKIAKARTENEDSNGVVDQKTINQMKRIHNLVAILK ECAGNEKEPLTLGKLKEINSDFIENFEE |
Msh4p (Saccharomyces cerevisiae) belongs to following protein families:
References:
| Title | Authors | Journal |
| Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction. | Ross-Macdonald P, Roeder GS | Cell Dec. 16, 1994 |
| Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae. | Murakami Y, Naitou M, Hagiwara H, Shibata T, Ozawa M, Sasanuma S, Sasanuma M, Tsuchiya Y, Soeda E, Yokoyama K, et al. | Nat Genet July 1, 1995 |
| Sequencing of a 23 kb fragment from Saccharomyces cerevisiae chromosome VI. | Naitou M, Ozawa M, Sasanuma SI, Kobayashi M, Hagiwara H, Shibata T, Hanaoka F, Watanabe K, Ono A, Yamazaki M, Tashiro H, Eki T, Murakami Y | Yeast Feb. 1, 1996 |
| Conserved properties between functionally distinct MutS homologs in yeast. | Pochart P, Woltering D, Hollingsworth NM | J Biol Chem Nov. 28, 1997 |
Last modification of this entry: Oct. 13, 2010.
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