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Msh5p |
Msh5p is involved in:
HRR in Saccharomyces cerevisiae
Keywords:
FUNCTION: Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis.
SUBUNIT: Heterooligomer of MSH4 and MSH5.
INTERACTION: P40965:MSH4; NbExp=2; IntAct=EBI-11377, EBI-11371;
MISCELLANEOUS: Two distinct classes of crossovers have been demonstrated in budding yeast. Class I is MSH4/MSH5 dependent and exhibits crossover interference. Class II is MUS81/MMS4 dependent and exhibits no interference.
SIMILARITY: Belongs to the DNA mismatch repair mutS family.
| NCBI GenPept GI number(s): |
6320047 |
| Species: | Saccharomyces cerevisiae |
Links to other databases:
| Database | ID | Link |
| Uniprot | Q12175 |
Q12175 |
| PFAM: | - |
Q12175 (Link - using uniprot id) |
| InterPro: | - |
Q12175 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MSHEWLISASETMRSIGNGEGLRDKGAVVANNDGEFNEGDTNREEDSSTI FSFDFDEEIVMCIDFSGGKLGCSILDYHTKTLKAFDQDYVVNKTTISSHD LIDDADMSSNDISLLLGLLIMEANPTVCLVPARLEDWIFDYIKTKCDEIN CRLELQPIKRFKKWDLLQSLQLRGHDNQTILNDILSNSKFTTTVTLGTVG CILANHEQLGEYNDSTASSNMVTGRLVQNAFEDVIHGIRYIDIRDRMVLD ENTISALHIFPTAHKLGHDKMMRNGFFSVFELFNQVSSDYARRILKSWLI NPLTNKKRIETRYSIIRTLLDKQNAIIFSDLSQSIKRCPDAFGFINQLRS GKSTLGTWSKVASFLEKGIAIFQLVSSLKLGSDEANILHDIKNKVDISAL KECLRKVETVIDFDTSRDTKTLTINTGVDNRLDECRNIYNHLEGILLDVA RETQIFLLNTMPQEDCKTTKSLEKLVNAVYIPQLGYLVTISVLMEPLLDG IPNLQWEEIFRSSENIYFKNGRVLELDETYGDIYGAISDFEIEILFSLQE QILRRKTQLTAYNILLSELEILLSFAQVSAERNYAEPQLVEDECILEIIN GRHALYETFLDNYIPNSTMIDGGLFSELSWCEQNKGRIIVVTGANASGKS VYLTQNGLIVYLAQIGCFVPAERARIGIADKILTRIRTQETVYKTQSSFL LDSQQMAKSLSLATEKSLILIDEYGKGTDILDGPSLFGSIMLNMSKSEKC PRIIACTHFHELFNENVLTENIKGIKHYCTDILISQKYNLLETAHVGEDH ESEGITFLFKVKEGISKQSFGIYCAKVCGLSRDIVERAEELSRMINRGDD VVQQCGNLTEKEMREFQKNQEIVKKFLSWDLDLETTTTSENLRLKLKNFL R |
Msh5p (Saccharomyces cerevisiae) belongs to following protein families:
References:
| Title | Authors | Journal |
| MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair. | Hollingsworth NM, Ponte L, Halsey C | Genes Dev July 15, 1995 |
| Analysis of a 23 kb region on the left arm of yeast chromosome IV. | Delaveau T, Blugeon C, Jacq C, Perea J | Yeast Dec. 1, 1996 |
| The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. | Jacq C, Alt-Morbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Blocker H, Blugeon C, Boskovic J, Brandt P, Bruckner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P, et al. | Nature May 1, 1997 |
| Conserved properties between functionally distinct MutS homologs in yeast. | Pochart P, Woltering D, Hollingsworth NM | J Biol Chem Nov. 28, 1997 |
Last modification of this entry: Oct. 13, 2010.
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