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Rad4p |
Protein FULL name:
Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein
Rad4p (Saccharomyces cerevisiae) is product of expression of RAD4 gene.
Rad4p is involved in:
NER in Saccharomyces cerevisiae
- Rad14 joins the complex in Saccharomyces cerevisiae
- Rad25 and Rad3 unwind DNA in Saccharomyces cerevisiae
- Rad4 recruitsTFIIH complex in Saccharomyces cerevisiae
- Rad4/Rad23 complex recognizes photoproduct in Saccharomyces cerevisiae
FUNCTION: Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.
INTERACTION: P18480:SNF5; NbExp=1; IntAct=EBI-14766, EBI-17546; P18888:SNF6; NbExp=1; IntAct=EBI-14766, EBI-17550;
SUBCELLULAR LOCATION: Nucleus.
MISCELLANEOUS: Present with 876 molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the XPC family.
| NCBI GenPept GI number(s): |
6321010 |
| Species: | Saccharomyces cerevisiae |
Links to other databases:
| Database | ID | Link |
| Uniprot | P14736 |
P14736 |
| PFAM: | - |
P14736 (Link - using uniprot id) |
| InterPro: | - |
P14736 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MNEDLPKEYFELIRKALNEKEAEKAPLSRRRRVRRKNQPLPDAKKKFKTG LNELPRESVVTVNLDSSDDGVVTVPTDDSVEEIQSSEEDYDSEEFEDVTD GNEVAGVEDISVEIKPSSKRNSDARRTSRNVCSNEERKRRKYFHMLYLVC LMVHGFIRNEWINSKRLSRKLSNLVPEKVFELLHPQKDEELPLRSTRKLL DGLKKCMELWQKHWKITKKYDNEGLYMRTWKEIEMSANNKRKFKTLKRSD FLRAVSKGHGDPDISVQGFVAMLRACNVNARLIMSCQPPDFTNMKIDTSL NGNNAYKDMVKYPIFWCEVWDKFSKKWITVDPVNLKTIEQVRLHSKLAPK GVACCERNMLRYVIAYDRKYGCRDVTRRYAQWMNSKVRKRRITKDDFGEK WFRKVITALHHRKRTKIDDYEDQYFFQRDESEGIPDSVQDLKNHPYYVLE QDIKQTQIVKPGCKECGYLKVHGKVGKVLKVYAKRDIADLKSARQWYMNG RILKTGSRCKKVIKRTVGRPKGEAEEEDERLYSFEDTELYIPPLASASGE ITKNTFGNIEVFAPTMIPGNCCLVENPVAIKAARFLGVEFAPAVTSFKFE RGSTVKPVLSGIVVAKWLREAIETAIDGIEFIQEDDNRKEHLLGALESWN TLLLKLRIRSKLNSTYGKIAEEEPNVTKEQNIADNHDNTETFMGGGFLPG IANHEARPYSEPSEPEDSLDYVSVDKAEESATDDDVGEDYSDFMKELEMS EESD |
Rad4p (Saccharomyces cerevisiae) belongs to following protein families:
References:
| Title | Authors | Journal |
| Cloning and nucleotide sequence analysis of the Saccharomyces cerevisiae RAD4 gene required for excision repair of UV-damaged DNA. | Gietz RD, Prakash S | Gene Dec. 1, 1988 |
| Nucleotide sequence of the wild-type RAD4 gene of Saccharomyces cerevisiae and characterization of mutant rad4 alleles. | Couto LB, Friedberg EC | J Bacteriol April 1, 1989 |
| The nucleotide sequence of Saccharomyces cerevisiae chromosome V. | Dietrich FS, Mulligan J, Hennessy K, Yelton MA, Allen E, Araujo R, Aviles E, Berno A, Brennan T, Carpenter J, Chen E, Cherry JM, Chung E, Duncan M, Guzman E, Hartzell G, Hunicke-Smith S, Hyman RW, Kayser A, Komp C, Lashkari D, Lew H, Lin D, Mosedale D, Davis RW, et al. | Nature May 1, 1997 |
| Global analysis of protein expression in yeast. | Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS | Nature Oct. 16, 2003 |
Last modification of this entry: Oct. 6, 2010.
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