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Mph1p |
Protein FULL name:
Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, binds to flap DNA and stimulates activity of Rad27p and Dna2p; mutations confer a mutator phenotype
Mph1p (Saccharomyces cerevisiae) is product of expression of MPH1 gene.
Mph1p is involved in:
HRR in Saccharomyces cerevisiae
Keywords:
FUNCTION: ATP-dependent DNA helicase involved in error-free DNA damage bypass through homologous recombination.
CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Belongs to the DEAH box helicase family. MPH1 subfamily.
SIMILARITY: Contains 1 helicase ATP-binding domain.
SIMILARITY: Contains 1 helicase C-terminal domain.
| NCBI GenPept GI number(s): |
6322192 |
| Species: | Saccharomyces cerevisiae |
Links to other databases:
| Database | ID | Link |
| Uniprot | P40562 |
P40562 |
| PFAM: | - |
P40562 (Link - using uniprot id) |
| InterPro: | - |
P40562 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MASADDYFSDFEDDELDKLYEKAINKSVKETITRRAVPVQKDLHDNVLPG QKTVYEEIQRDVSFGPTHHELDYDALSFYVYPTNYEVRDYQYTIVHKSLF QNTLCAIPTGMGKTFIASTVMLNYFRWTKKAKIIFTAPTRPLVAQQIKAC LGITGIPSDQTAILLDKSRKNREEIWANKRVFFATPQVVENDLKRGVLDP KDIVCLVIDEAHRATGSSAYTNVVKFIDRFNSSYRLLALTATPASDLEGV QEVVNNLDISKIEIRTEESMDIVKYMKKRKKEKIEVPLLLEIEDIIEQLG MAVKPVLQQAIELGIYEECDPSQINAFKAMQQSQKIIANPTIPEGIKWRN FFILQLLNNVGQMLKRLKIYGIRTFFNYFQNKCTEFTTKYNLKKSTNKIA AEFYYHPILKNIKNQCENYLSDPKFVGHGKLQCVRDELMDFFQKRGSDSR VIIFTELRESALEIVKFIDSVADDQIRPHIFIGQARAKEGFDEVKYTRKH APKGRKKVERLHRQEQEKFLEAERTKRAANDKLERSARRTGSSEEAQISG MNQKMQKEVIHNFKKGEYNVLVCTSIGEEGLDIGEVDLIICYDTTSSPIK NIQRMGRTGRKRDGKIVLLFSSNESYKFERAMEDYSTLQALISKQCIDYK KSDRIIPEDIIPECHETLITINDENEIINEMEDVDEVIRYATQCMMGKKV KPKKAITKKKRVQENKKPKKFFMPDNVETSIVSASTLINKFLVNESGGKQ LVTSNENPSKKRKIFKALDNLENDSTEEASSSLETEDEEVSDDNNVFIAE GQNGCQKDLETAIIRTGESLTTLKPLHNFERPNMALFVNDCGLPTKIEKN VKDIRGNQHNLEKEKSCTVDKNNMVLSLDDWNFFRNRYIPEGVSFDVEPN FVQYTKGVKVPHCHKVSKIITLFNDESNDNKKRTIDMNYTKCLARGMLRD EKKFVKVNDKSQVDNNSVNHDSSQSFTLSNAELDDILGSDSDF |
Mph1p (Saccharomyces cerevisiae) belongs to following protein families:
References:
| Title | Authors | Journal |
| Nucleotide sequence and analysis of the centromeric region of yeast chromosome IX. | Voss H, Tamames J, Teodoru C, Valencia A, Sensen C, Wiemann S, Schwager C, Zimmermann J, Sander C, Ansorge W | Yeast Feb. 1, 1995 |
| The nucleotide sequence of Saccharomyces cerevisiae chromosome IX. | Churcher C, Bowman S, Badcock K, Bankier A, Brown D, Chillingworth T, Connor R, Devlin K, Gentles S, Hamlin N, Harris D, Horsnell T, Hunt S, Jagels K, Jones M, Lye G, Moule S, Odell C, Pearson D, Rajandream M, Rice P, Rowley N, Skelton J, Smith V, Barrell B, et al. | Nature May 1, 1997 |
| MPH1, a yeast gene encoding a DEAH protein, plays a role in protection of the genome from spontaneous and chemically induced damage. | Scheller J, Schurer A, Rudolph C, Hettwer S, Kramer W | Genetics July 1, 2000 |
| Global analysis of protein localization in budding yeast. | Huh WK, Falvo JV, Gerke LC, Carroll AS, Howson RW, Weissman JS, O'Shea EK | Nature Oct. 16, 2003 |
| Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from Homologous recombination, but not from postreplicative repair. | Schurer KA, Rudolph C, Ulrich HD, Kramer W | Genetics April 1, 2004 |
| Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase. | Prakash R, Krejci L, Van Komen S, Anke Schurer K, Kramer W, Sung P | J Biol Chem March 4, 2005 |
| Genome-wide requirements for resistance to functionally distinct DNA-damaging agents. | Lee W, St Onge RP, Proctor M, Flaherty P, Jordan MI, Arkin AP, Davis RW, Nislow C, Giaever G | PLoS Genet Aug. 1, 2005 |
| A multidimensional chromatography technology for in-depth phosphoproteome analysis. | Albuquerque CP, Smolka MB, Payne SH, Bafna V, Eng J, Zhou H | Mol Cell Proteomics July 1, 2008 |
Last modification of this entry: Oct. 13, 2010.
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