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Met18p |
Protein FULL name:
DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance
Met18p (Saccharomyces cerevisiae) is product of expression of MET18 gene.
Met18p is involved in:
NER in Saccharomyces cerevisiae
Keywords:
- transcription-coupled repair NER (TCR-NER)
- nucleotide excision repair (NER)
- global genome repair NER (GGR-NER)
FUNCTION: Involved in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. Required for both transcription-coupled and global NER. It probably does not participate directly in NER and POL II transcription, but exerts its biological effects by influencing the activity of TFIIH and possibly other DNA repair and transcription factors as an upstream regulatory element. Involved in sporulation and possibly in the RAD52 recombinational repair pathway.
INTERACTION: P38829:-; NbExp=1; IntAct=EBI-11492, EBI-24704; Q99278:MED11; NbExp=2; IntAct=EBI-11492, EBI-27213;
SUBCELLULAR LOCATION: Nucleus (By similarity).
MISCELLANEOUS: Present with 3150 molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the MET18/MMS19 family.
SIMILARITY: Contains 13 HEAT repeats.
| NCBI GenPept GI number(s): |
6322063 |
| Species: | Saccharomyces cerevisiae |
Links to other databases:
| Database | ID | Link |
| Uniprot | P40469 |
P40469 |
| PFAM: | - |
P40469 (Link - using uniprot id) |
| InterPro: | - |
P40469 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MTPDELNSAVVTFMANLNIDDSKANETASTVTDSIVHRSIKLLEVVVALK DYFLSENEVERKKALTCLTTILAKTPKDHLSKNECSVIFQFYQSKLDDQA LAKEVLEGFAALAPMKYVSINEIAQLLRLLLDNYQQGQHLASTRLWPFKI LRKIFDRFFVNGSSTEQVKRINDLFIETFLHVANGEKDPRNLLLSFALNK SITSSLQNVENFKEDLFDVLFCYFPITFKPPKHDPYKISNQDLKTALRSA ITATPLFAEDAYSNLLDKLTASSPVVKNDTLLTLLECVRKFGGSSILENW TLLWNALKFEIMQNSEGNENTLLNPYNKDQQSDDVGQYTNYDACLKIINL MALQLYNFDKVSFEKFFTHVLDELKPNFKYEKDLKQTCQILSAIGSGNVE IFNKVISSTFPLFLINTSEVAKLKLLIMNFSFFVDSYIDLFGRTSKESLG TPVPNNKMAEYKDEIIMILSMALTRSSKAEVTIRTLSVIQFTKMIKMKGF LTPEEVSLIIQYFTEEILTDNNKNIYYACLEGLKTISEIYEDLVFEISLK KLLDLLPDCFEEKIRVNDEENIHIETILKIILDFTTSRHILVKESITFLA TKLNRVAKISKSREYCFLLISTIYSLFNNNNQNENVLNEEDALALKNAIE PKLFEIITQESAIVSDNYNLTLLSNVLFFTNLKIPQAAHQEELDRYNELF ISEGKIRILDTPNVLAISYAKILSALNKNCQFPQKFTVLFGTVQLLKKHA PRMTETEKLGYLELLLVLSNKFVSEKDVIGLFDWKDLSVINLEVMVWLTK GLIMQNSLESSEIAKKFIDLLSNEEIGSLVSKLFEVFVMDISSLKKFKGI SWNNNVKILYKQKFFGDIFQTLVSNYKNTVDMTIKCNYLTALSLVLKHTP SQSVGPFINDLFPLLLQALDMPDPEVRVSALETLKDTTDKHHTLITEHVS TIVPLLLSLSLPHKYNSVSVRLIALQLLEMITTVVPLNYCLSYQDDVLSA LIPVLSDKKRIIRKQCVDTRQVYYELGQIPFE |
Met18p (Saccharomyces cerevisiae) belongs to following protein families:
References:
| Title | Authors | Journal |
| Three additional genes involved in pyrimidine dimer removal in Saccharomyces cerevisiae: RAD7, RAD14 and MMS19. | Prakash L, Prakash S | Mol Gen Genet Nov. 1, 1979 |
| Dual requirement for the yeast MMS19 gene in DNA repair and RNA polymerase II transcription. | Lauder S, Bankmann M, Guzder SN, Sung P, Prakash L, Prakash S | Mol Cell Biol Dec. 1, 1996 |
| The nucleotide sequence of Saccharomyces cerevisiae chromosome IX. | Churcher C, Bowman S, Badcock K, Bankier A, Brown D, Chillingworth T, Connor R, Devlin K, Gentles S, Hamlin N, Harris D, Horsnell T, Hunt S, Jagels K, Jones M, Lye G, Moule S, Odell C, Pearson D, Rajandream M, Rice P, Rowley N, Skelton J, Smith V, Barrell B, et al. | Nature May 1, 1997 |
| Saccharomyces cerevisiae mms19 mutants are deficient in transcription-coupled and global nucleotide excision repair. | Lombaerts M, Tijsterman M, Verhage RA, Brouwer J | Nucleic Acids Res Oct. 15, 1997 |
| Global analysis of protein expression in yeast. | Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS | Nature Oct. 16, 2003 |
| Quantitative trait loci mapped to single-nucleotide resolution in yeast. | Deutschbauer AM, Davis RW | Nat Genet Dec. 1, 2005 |
Last modification of this entry: Oct. 19, 2010.
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