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ung

Unnamed Gene ID: 947067

Known also as: ECK2578; JW2564;


NCBI Gene ID: 947067
Species: Escherichia coli strain K-12 substr. MG1655

UDG and Ndk form a complex (Goswami, 2006). [More information is available at EcoGene: EG11058]. Uracil can be generated in DNA as a result of misincorporation by DNA polymerase, spontaneous deamination of cytosine, and deamination of cytosine induced by bisulfite or nitrous acid. [More information is available at EcoCyc: EG11058].


Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
el-Hajj HH, Wang L, Weiss B Multiple mutant of Escherichia coli synthesizing virtually thymineless DNA during limited growth. J Bacteriol July 1, 1992
Lundquist AJ, Beger RD, Bennett SE, Bolton PH, Mosbaugh DW Site-directed mutagenesis and characterization of uracil-DNA glycosylase inhibitor protein. Role of specific carboxylic amino acids in complex formation with Escherichia coli uracil-DNA glycosylase. J Biol Chem Aug. 22, 1997
Saparbaev M, Laval J 3,N4-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase. Proc Natl Acad Sci U S A July 21, 1998
Ravishankar R, Bidya Sagar M, Roy S, Purnapatre K, Handa P, Varshney U, Vijayan M X-ray analysis of a complex of Escherichia coli uracil DNA glycosylase (EcUDG) with a proteinaceous inhibitor. The structure elucidation of a prokaryotic UDG. Nucleic Acids Res Nov. 1, 1998
Putnam CD, Shroyer MJ, Lundquist AJ, Mol CD, Arvai AS, Mosbaugh DW, Tainer JA Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase. J Mol Biol March 26, 1999

Last modification of this entry: Oct. 6, 2010.

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