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Bujnicki Lab Homepage

TLS in Saccharomyces cerevisiae

translesion synthesis

(also known as DNA damage tolerance)

Proteins:
Rad30p
Rev3p


DNA repair constitutes an important defense system by removing the lesions from DNA. However, some DNA lesions can persist in the genome during replication due to limited cellular repair and/or newly formed damage at the S phase of the cell cycle. Since many lesions block replicative DNA polymerases, cells have evolved a damage tolerance response to enable replication of the damaged DNA templates. Lesion bypass represents one of the damage tolerance mechanisms, and requires a DNA polymerase to copy the damaged DNA template. DNA synthesis (nucleotide incorporation) opposite a template lesion is also referred to as translesion synthesis. Depending on the outcome, translesion synthesis is further divided into error-free and error-prone translesion syntheses.

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