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Bujnicki Lab Homepage

MMR: ExoI excises errorenous strand heteroduplex DNA with nick 5' to mismatch

[Homo sapiens]





The excision starts either at pre-existing 5' nick or at the nick introduced by MutLalpha.


This is the reaction from:
Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex, bound by ExoI (distant site) in Homo sapiens
to
Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex and ExoI, with partially excised errorenous strand in Homo sapiens


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