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Bujnicki Lab Homepage

Heteroduplex DNA with nick 3' to mismatch

[Homo sapiens]





The daughter DNA strand (upper) contains a mismatched base (red).
The strand discrimination signal, which probably corresponds to strand discontinuities at the replication fork, is located near the mismatch. In vitro, PCNA and RFC proteins are bound to the strand discontinuity that must be present in the DNA substrate.

Heteroduplex DNA with nick 3' to mismatch is part of following pathways: This DNA state is a previous state in the following reactions:

Reaction Previous state Following state
MutSalpha binds mismatch in heteroduplex DNA with nick 3' to mismatch in Homo sapiens Heteroduplex DNA with nick 3' to mismatch in Homo sapiens Mismatch in heteroduplex DNA with nick 3' to mismatch bound by MutSalpha in Homo sapiens

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