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MMR: ExoI excises errorenous strand heteroduplex DNA with nick 5' to mismatch

[Homo sapiens]

The excision starts either at pre-existing 5' nick or at the nick introduced by MutLalpha.

This is the reaction from:

Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex, bound by ExoI (distant site) in Homo sapiens

to

Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex and ExoI, with partially excised errorenous strand in Homo sapiens

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