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"FANCI is a second monoubiquitinated member of the Fanconi anemia pathway."

Sims AE, Spiteri E, Sims RJ 3rd, Arita AG, Lach FP, Landers T, Wurm M, Freund M, Neveling K, Hanenberg H, Auerbach AD, Huang TT



Published June 1, 2007 in Nat Struct Mol Biol volume 14 .

Pubmed ID: 17460694

Abstract:
Activation of the Fanconi anemia (FA) DNA damage-response pathway results in the monoubiquitination of FANCD2, which is regulated by the nuclear FA core ubiquitin ligase complex. A FANCD2 protein sequence-based homology search facilitated the discovery of FANCI, a second monoubiquitinated component of the FA pathway. Biallelic mutations in the gene coding for this protein were found in cells from four FA patients, including an FA-I reference cell line.


This publication refers to following REPAIRtoire entries:

Genes
Proteins


Last modification of this entry: Oct. 6, 2010

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