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Protein FULL name:
adenine DNA glycosylase [Escherichia coli str. K-12 substr. MG1655].
MutY (Escherichia coli strain K-12 substr. MG1655) is product of expression of mutY gene.
MutY is involved in:
BER in Escherichia coli strain K-12 substr. MG1655
FUNCTION: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8- oxoguanine (8-oxo-dGTP).
COFACTOR: Binds 1 4Fe-4S cluster. The cluster is not important for the catalytic activity, but which is probably involved in the proper positioning of the enzyme along the DNA strand.
SIMILARITY: Belongs to the nth/mutY family.
Links to other databases:
MutY (Escherichia coli strain K-12 substr. MG1655) is able to recognize following damages:
Last modification of this entry: Oct. 13, 2010.
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