REPAIRtoire - a database of DNA repair pathways

Welcome! Click here to login or here to register.
Home
Proteins
DNA damage
Diseases
Homologs
Pathways
Keywords
Publications
Draw a picture
 
Search
 
Links
Help
Contact





Bujnicki Lab Homepage

Keyword: DNA N-glycosylase


DNA glycosylases (EC 3.2.2.) are a family of enzymes involved in base excision repair (BER) and catalyze the first step of this process. They recognize and remove the damaged nitrogenous base while leaving the sugar-phosphate backbone intact, creating an apurinic/apyrimidinic site, commonly referred to as an AP site. This is accomplished by flipping the damaged base out of the double helix followed by cleavage of the N-glycosidic bond. There are two main classes of glycosylases: (i) monofunctional and (ii) bifunctional.

Monofunctional glycosylases have only glycosylase activity and to cleave the N-glycosidic bond, use an activated water molecule to attack carbon 1 of the substrate.

Based on structural similarity, glycosylases are grouped into four superfamilies. The UDG and AAG families contain small, compact glycosylases (monofunctional), whereas the MutM/Fpg and HhH-GPD families comprise larger enzymes with multiple domains (bifunctional).



REPAIRtoire objects related to the DNA N-glycosylase keyword:

Category name Results
DNA damages
Proteins
Welcome stranger! Click here to login or here to register.
Valid HTML 4.01! This site is Emacs powered. Made with Django.