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Protein FULL name:
DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress
Protein SHORT name:
NTG1, FUN33, SCR1
Ntg1p (Saccharomyces cerevisiae) is product of expression of NTG1 gene.
Ntg1p is involved in:
BER in Saccharomyces cerevisiae
FUNCTION: Excision repair N-glycosylase involved in the repair of DNA base damage in the mitochondria. NTG1 can use dihydrothymine, urea, and uracil glycol are substrates.
SUBCELLULAR LOCATION: Mitochondrion. Note=Mitochondrial transmembrane space or matrix.
SIMILARITY: Belongs to the nth/mutY family.
Links to other databases:
Ntg1p (Saccharomyces cerevisiae) is able to recognize following damages:
Ntg1p (Saccharomyces cerevisiae) belongs to following protein families:
Last modification of this entry: Oct. 14, 2010.
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