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Bujnicki Lab Homepage

thymidine glycol

(5,6-dihydroxy-5,6-dihydrothymidine-5'-monophosphate)



Smiles represantation:
[H]O[C@@]1([H])C([H])([H])[C@@]([H])(O[C@]1([H])C([H])([H])OP(O)(O)=O)N1C(=O)N([H])C(=O)[C@@](O[H])(C([H])([H])[H])[C@@]1([H])O[H]


One of the principal DNA lesions induced by oxidation and ionizing radiation, has been investigated in Escherichia coli. Thymine glycol was positioned at a unique site in the single-stranded genome of a bacteriophage M13mp19 derivative. Replication of the genome in E. coli yielded targeted mutations at a frequency of 0.3%; the mutations were exclusively T to C transitions.


Download [.mol file for thymidine glycol]

Sources:

Recognizing proteins:
Protein Species
NEIL1 Homo sapiens
NEIL2 Homo sapiens
NTH Homo sapiens
Ntg1p Saccharomyces cerevisiae
Nth Escherichia coli


Keywords:

Last modification of this entry: Oct. 16, 2010.

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