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Mismatch in heteroduplex DNA with nick 5' to mismatch bound by MutSalpha
[Homo sapiens]
| MutS searches binds to DNA in the nucleotide-free or ADP-bound state. The binding of MutS to DNA induces bending of both homo- and heteroduplex DNA. When MutS encounters the mismatch, a bend is turned into a sharp kink. This triggers a conformational change in the protein and the exchange of ADP to ATP. |
Mismatch in heteroduplex DNA with nick 5' to mismatch bound by MutSalpha is part of following pathways: This DNA state is a resulting state in the following reactions:
| Reaction | Previous state | Following state |
| MutSalpha binds mismatch in heteroduplex DNA with nick 5' to mismatch in Homo sapiens | Heteroduplex DNA with nick 5' to mismatch in Homo sapiens | Mismatch in heteroduplex DNA with nick 5' to mismatch bound by MutSalpha in Homo sapiens |
This DNA state is a previous state in the following reactions:
| Reaction | Previous state | Following state |
| MutSalpha interacts with MutLalpha on heteroduplex DNA with nick 5' to mismatch in Homo sapiens | Mismatch in heteroduplex DNA with nick 5' to mismatch bound by MutSalpha in Homo sapiens | Mismatch in heteroduplex DNA with nick 5' to mismatch bound by MutSalpha-MutLalpha complex in Homo sapiens |
References:
| Authors | Title | Journal |
| Antony E, Hingorani MM | Asymmetric ATP binding and hydrolysis activity of the Thermus aquaticus MutS dimer is key to modulation of its interactions with mismatched DNA. |
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| Jacobs-Palmer E, Hingorani MM | The effects of nucleotides on MutS-DNA binding kinetics clarify the role of MutS ATPase activity in mismatch repair. |
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| Lamers MH, Georgijevic D, Lebbink JH, Winterwerp HH, Agianian B, de Wind N, Sixma TK | ATP increases the affinity between MutS ATPase domains. Implications for ATP hydrolysis and conformational changes. |
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| Tessmer I, Yang Y, Zhai J, Du C, Hsieh P, Hingorani MM, Erie DA | Mechanism of MutS searching for DNA mismatches and signaling repair. |
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| Wang H, Yang Y, Schofield MJ, Du C, Fridman Y, Lee SD, Larson ED, Drummond JT, Alani E, Hsieh P, Erie DA | DNA bending and unbending by MutS govern mismatch recognition and specificity. |
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Keywords:
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