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Mismatch in heteroduplex DNA with nick 5' to mismatch bound by MutSalpha-MutLalpha complex
[Homo sapiens]
| After recognizing the error in DNA, ATP-bound MutS physically interacts with the MutL protein, which then activates a chain of events leading to the repair of the error. It is not yet fully resolved whether Muts interacts with MutL on the mismatch or after leaving the mismatch. |
Mismatch in heteroduplex DNA with nick 5' to mismatch bound by MutSalpha-MutLalpha complex is part of following pathways: This DNA state is a resulting state in the following reactions:
| Reaction | Previous state | Following state |
| MutSalpha interacts with MutLalpha on heteroduplex DNA with nick 5' to mismatch in Homo sapiens | Mismatch in heteroduplex DNA with nick 5' to mismatch bound by MutSalpha in Homo sapiens | Mismatch in heteroduplex DNA with nick 5' to mismatch bound by MutSalpha-MutLalpha complex in Homo sapiens |
This DNA state is a previous state in the following reactions:
| Reaction | Previous state | Following state |
| MutLalpha nicks heteroduplex DNA with nick 5' to mismatch in Homo sapiens | Mismatch in heteroduplex DNA with nick 5' to mismatch bound by MutSalpha-MutLalpha complex in Homo sapiens | Mismatch in heteroduplex DNA with nick 5' to mismatch and nicks around mismatch bound by MutSalpha-MutLalpha complex in Homo sapiens |
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