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Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex, bound by ExoI (distant site)
[Homo sapiens]
| Although not drawn on the picture, physical interactions take place between MutSalpha and ExoI. |
Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex, bound by ExoI (distant site) is part of following pathways: This DNA state is a resulting state in the following reactions:
| Reaction | Previous state | Following state |
| ExoI loads onto heteroduplex DNA with nick 5' to mismatch (distant site) in Homo sapiens | Mismatch in heteroduplex DNA with nick 5' to mismatch and nicks around mismatch bound by MutSalpha-MutLalpha complex in Homo sapiens | Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex, bound by ExoI (distant site) in Homo sapiens |
This DNA state is a previous state in the following reactions:
| Reaction | Previous state | Following state |
| ExoI excises errorenous strand heteroduplex DNA with nick 5' to mismatch in Homo sapiens | Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex, bound by ExoI (distant site) in Homo sapiens | Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex and ExoI, with partially excised errorenous strand in Homo sapiens |
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