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Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex, bound by ExoI (proximal site)
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ExoI loads onto heteroduplex DNA with nick 5' to mismatch (on proximal site) in Homo sapiens | Mismatch in heteroduplex DNA with nick 5' to mismatch and nicks around mismatch bound by MutSalpha-MutLalpha complex in Homo sapiens | Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex, bound by ExoI (proximal site) in Homo sapiens |
Reaction | Previous state | Following state |
ExoI excises errorenous strand heteroduplex DNA with nick 5' to mismatch (proximal site) in Homo sapiens | Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex, bound by ExoI (proximal site) in Homo sapiens | Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex and ExoI, with partially excised errorenous strand (proximal site) in Homo sapiens |