REPAIRtoire - a database of DNA repair pathways

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POLK

polymerase (DNA directed) kappa

On chromosome: 5q13
Known also as: DINP; POLQ; DINB1;

NCBI Gene ID:	51426
NCBI Ensembl Id:	ENSG00000122008
MIM Id: (from NCBI OMIM database)	605650
Species:	Homo sapiens

External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 [PubMed 17317631]).[supplied by OMIM]

Gene sequence:

[Download sequence]

Proteins coded by this gene:

POLK (Homo sapiens)

References:

Authors	Title	Journal
Ogi T, Kato T Jr, Kato T, Ohmori H	Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein dinB.	Genes Cells Nov. 1, 1999
Fukuda H, Takamura-Enya T, Masuda Y, Nohmi T, Seki C, Kamiya K, Sugimura T, Masutani C, Hanaoka F, Nakagama H	Translesional DNA synthesis through a C8-guanyl adduct of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Vitro: REV1 inserts dC opposite the lesion, and DNA polymerase kappa potentially catalyzes extension reaction from the 3'-dC terminus.	J Biol Chem Sept. 18, 2009
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	Mol Med Jan. 1, 2010
Katafuchi A, Sassa A, Niimi N, Gruz P, Fujimoto H, Masutani C, Hanaoka F, Ohta T, Nohmi T	Critical amino acids in human DNA polymerases eta and kappa involved in erroneous incorporation of oxidized nucleotides.	Nucleic Acids Res Feb. 1, 2010
Monsees GM, Kraft P, Chanock SJ, Hunter DJ, Han J	Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.	Breast Cancer Res Treat May 23, 2010

Last modification of this entry: Oct. 6, 2010.

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