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Trp53transformation related protein 53 |
Known also as: bbl; bfy; bhy; p44; p53; Tp53;
| NCBI Gene ID: | 22059 |
| NCBI Ensembl Id: | ENSMUSG00000059552 |
| Species: | Mus musculus |
| This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Wadhwa R, Sugihara T, Yoshida A, Duncan EL, Hardeman EC, Nomura H, Reddel RR, Kaul SC | Cloning and characterization of a novel gene, striamin, that interacts with the tumor suppressor protein p53. | J Biol Chem May 21, 1999 |
| Wilkinson DS, Ogden SK, Stratton SA, Piechan JL, Nguyen TT, Smulian GA, Barton MC | A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene. | Mol Cell Biol Jan. 1, 2005 |
| Watanabe-Fukunaga R, Iida S, Shimizu Y, Nagata S, Fukunaga R | SEI family of nuclear factors regulates p53-dependent transcriptional activation. | Genes Cells Aug. 1, 2005 |
| Kulesz-Martin M, Lagowski J, Fei S, Pelz C, Sears R, Powell MB, Halaban R, Johnson J | Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles. | J Investig Dermatol Symp Proc Nov. 1, 2005 |
Last modification of this entry: Oct. 6, 2010.
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