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LIG1ligase I, DNA, ATP-dependent |
Known also as: MGC117397; MGC130025;
| NCBI Gene ID: | 3978 |
| NCBI Ensembl Id: | ENSG00000105486 |
| MIM Id: (from NCBI OMIM database) | 126391 |
| Species: | Homo sapiens |
| LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. [provided by RefSeq] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Barnes DE, Johnston LH, Kodama K, Tomkinson AE, Lasko DD, Lindahl T | Human DNA ligase I cDNA: cloning and functional expression in Saccharomyces cerevisiae. | Proc Natl Acad Sci U S A Sept. 1, 1990 |
| Bentley D, Selfridge J, Millar JK, Samuel K, Hole N, Ansell JD, Melton DW | DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability. | Nat Genet Aug. 1, 1996 |
| Bambara RA, Murante RS, Henricksen LA | Enzymes and reactions at the eukaryotic DNA replication fork. | J Biol Chem Jan. 21, 1997 |
| Grawunder U, Zimmer D, Fugmann S, Schwarz K, Lieber MR | DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. | Mol Cell Oct. 1, 1998 |
Last modification of this entry: Oct. 6, 2010.
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