• 1

About Laboratory Of Bioinformatics And Protein Engineering

Our group is involved in theoretical and experimental research on nucleic acids and proteins. The current focus is on RNA sequence-structure-function relationships (in particular 3D modeling), RNA-protein complexes, and enzymes acting on RNA.
 
We study the rules that govern the sequence-structure-function relationships in proteins and nucleic acids and use the acquired knowledge to predict structures and functions for uncharacterized gene products, to alter the known structures and functions of proteins and RNAs and to engineer molecules with new properties.
 
Our key strength is in the integration of various types of theoretical and experimental analyses. We develop and use computer programs for modeling of protein three-dimensional structures based on heterogenous, low-resolution, noisy and ambivalent experimental data. We are also involved in genome-scale phylogenetic analyses, with the focus on identification of proteins that belong to particular families. Subsequently, we characterize experimentally the function of the most interesting new genes/proteins identified by bioinformatics. We also use theoretical predictions to guide protein engineering, using rational and random approaches. Our ultimate goal is to identify complete sets of enzymes involved in particular metabolic pathways (e.g. RNA modification, DNA repair) and to design proteins with new properties, in particular enzymes with new useful functions, which have not been observed in the nature.
 
We are well-equipped with respect to both theoretical and experimental analyses. Our lab offers excellent environment for training of young researchers in both bioinformatics and molecular biology/biochemistry of protein-nucleic acid interactions.


More Good Science

 

We currently offer the following positions in the Bujnicki group in IIMCB, Warsaw, Poland

 

  1. Internship for MSc student in computational modeling of structure of nucleic acids
     

 

red - jobs focused on software development (with some molecular modeling)
orange - jobs focused on modeling and data analyses (with some software development)
green - jobs focused on experimental biochemistry and biophysics

 


 

Internship for MSc student
in computational modeling of structure of nucleic acids

 

Our big aim is to characterize nucleic acid molecules from a structural and functional point of view. Towards this goal, the development of bioinformatic tools for secondary and tertiary structure prediction of nucleic acids and their complexes, is of outmost importance. We have developed tools for the modeling of RNA 3D structure, and have become one of the most successful RNA modeling teams in the world: see rankings of RNA Puzzles. We offer you a chance to be a part of this success and to participate in a project “Bridging the gap: DNA catalysis explained” (2018/31/D/NZ2/01883), led by Dr. Almudena Ponce-Salvatierra and funded within the SONATA program of the Polish National Science Centre. In this project we focus on DNAzymes - synthetic, single-stranded DNA molecules that are capable of catalyzing chemical reactions.

You will apply your skills to participate in the development of bioinformatics programs. You will learn a lot and, if you are successful, you will be a co-author of a scientific publication.

Requirements:

  • The candidate must be enrolled in MSc studies in computer science or a related area.
  •  Proactive approach to achieving tasks and objectives, good interpersonal skills, a collaborative attitude
  • Documented experience in computational biology, bioinformatics, molecular modeling or in computer programming (preferably Python or C/C++)
  • Very good written and oral communication in English

Priority will be given to candidates with expertise most relevant to the project and to the general profile of the laboratory. The ability and interest to pursue challenging, interdisciplinary problems, and the ability to deliver results are essential.

We offer:

  • Fellowship starting with 1500 PLN/month (depending on qualifications)
  • Appointment starting as soon as possible/June 2021 for 3 months with the possibility of extension
  • Participation in courses, scientific training, support from peers, and academic mentoring

 
You will be a key member of a group working on a focused scientific project with well-defined goals that combines a big scientific challenge with opportunities to collaborate with other researchers. You will have access to modern equipment and support from other experienced researchers. The project provides opportunities for extensive interdisciplinary collaborations within the team and in the institute (e.g. with software developers, molecular modelers and experimentalists), as well as international collaborations with academia and industry. You will have many chances to make your collaborative research a success and you will be expected to present your results at scientific conferences and co-authorize scientific publications, and ultimately to include them in your PhD thesis.
Candidates will be selected in an open competition, according to the procedure complying with the rules of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers as a part of HR Excellence in Research strategy https://bit.ly/2OBshQU

How to apply:

  • We will collect applications until June 4th 2021
  • Apply now (or ask any questions you may have) to employment@genesilico.pl   
  • In the subject include "MSc-SONATA-student" and your first and last name.
  • Your application must be in English and should contain a CV, a motivation letter (What is your scientific dream and how to you want to fulfill it? What are your key strengths? Why do you want to work with us?), a list of your significant achievements, and contacts to at least two potential referees, including at least one former or current direct supervisor.
  • Please include the following statement in yourCurriculum vitae: “I hereby agree to the processing of my personal data, included in the application documents by the International Institute of Molecular and Cell Biology in Warsaw, 4 Księcia Trojdena Street, 02-109 Warsaw, for the purpose of carrying out the current recruitment process.” Your personal data will be processed for the purpose of the recruitment procedure by the International Institute of Molecular and Cell Biology in Warsaw. Full information is available under the link https://bit.ly/3ut6yKe.
  • Best candidates will be invited for an interview that will take place in early-mid June.

 

 

 

 


 

 

Frequently asked questions:

 
Q: Is health insurance provided?
A: For postdoctoral and technician positions associated with a full work contract ("umowa o pracę"), full health insurance and social security (ZUS) is included. For undergraduate and gratuate students, and for volunteers, basic health insurance is provided, and if they wish, they may insure themselves individually to make their contribution to ZUS.
 
Q: Are references required?
A: Yes, references are an important part of the selection process and candidates for postdoctoral positions are asked to provide at least two names of referees (one name for students), including at least one former or current supervisor.
 
Q: I am not from Poland and I don't speak Polish. Am I eligible to apply?
A: Yes, IIMCB welcomes applications from outside Poland. IIMCB has an international culture, and the official working language is English.