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TREX2
three prime repair exonuclease 2
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On chromosome: Xq28
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This gene encodes a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity. [provided by RefSeq]
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Gene sequence:
Proteins coded by this gene:
References:
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Authors
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Title
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Journal
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Mazur DJ, Perrino FW
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Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases.
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J Biol Chem
July 9, 1999
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Hur JW, Sung YK, Shin HD, Park BL, Cheong HS, Bae SC
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TREX1 polymorphisms associated with autoantibodies in patients with systemic lupus erythematosus.
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Rheumatol Int
June 1, 2008
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Perrino FW, de Silva U, Harvey S, Pryor EE Jr, Cole DW, Hollis T
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Cooperative DNA binding and communication across the dimer interface in the TREX2 3' --> 5'-exonuclease.
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J Biol Chem
Aug. 1, 2008
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Dumitrache LC, Hu L, Hasty P
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TREX2 exonuclease defective cells exhibit double-strand breaks and chromosomal fragments but not Robertsonian translocations.
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Mutat Res
March 9, 2009
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de Silva U, Perrino FW, Hollis T
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DNA binding induces active site conformational change in the human TREX2 3'-exonuclease.
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Nucleic Acids Res
April 1, 2009
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Last modification of this entry: Oct. 6, 2010.
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