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ALKBH2alkB, alkylation repair homolog 2 (E. coli) |
Known also as: ABH2; FLJ99103; MGC90512;
| NCBI Gene ID: | 121642 |
| NCBI Ensembl Id: | ENSG00000189046 |
| MIM Id: (from NCBI OMIM database) | 610602 |
| Species: | Homo sapiens |
| The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM] |
Gene sequence:
| [Download sequence] |
Proteins coded by this gene:
References:
| Authors | Title | Journal |
| Duncan T, Trewick SC, Koivisto P, Bates PA, Lindahl T, Sedgwick B | Reversal of DNA alkylation damage by two human dioxygenases. | Proc Natl Acad Sci U S A Dec. 24, 2002 |
| Yang CG, Yi C, Duguid EM, Sullivan CT, Jian X, Rice PA, He C | Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA. | Nature April 24, 2008 |
| Jia G, Yang CG, Yang S, Jian X, Yi C, Zhou Z, He C | Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. | FEBS Lett Oct. 15, 2008 |
Last modification of this entry: Oct. 6, 2010.
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