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ada
Unnamed Gene ID: 946710
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Known also as: ECK2205; JW2201;
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The Ada N-terminal domain acts as a transcriptional activator of ada, alkA, alkB and aidB. [More information is available at EcoGene: EG10029]. O6-methylguanine and O4-methylthymine are the major mutagenic lesions resulting from exposure of DNA to simple alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), N-methyl-N-nitrosourea (MNU) and, to a lesser degree, methane methanesulfonate (MMS). [More information is available at EcoCyc: EG10029].
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Gene sequence:
Proteins coded by this gene:
References:
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Authors
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Title
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Journal
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Jeggo P
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Isolation and characterization of Escherichia coli K-12 mutants unable to induce the adaptive response to simple alkylating agents.
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J Bacteriol
Sept. 1, 1979
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Adhya S, Garges S
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Positive control.
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J Biol Chem
July 5, 1990
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Takano K, Nakamura T, Sekiguchi M
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Roles of two types of O6-methylguanine-DNA methyltransferases in DNA repair.
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Mutat Res
Feb. 1, 1991
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Shevell DE, Walker GC
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A region of the Ada DNA-repair protein required for the activation of ada transcription is not necessary for activation of alkA.
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Proc Natl Acad Sci U S A
Oct. 15, 1991
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Myers LC, Terranova MP, Nash HM, Markus MA, Verdine GL
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Zinc binding by the methylation signaling domain of the Escherichia coli Ada protein.
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Biochemistry
May 19, 1992
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Last modification of this entry: Oct. 6, 2010.
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