REPAIRtoire - a database of DNA repair pathways

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Unnamed Gene ID: 946710

Known also as: ECK2205; JW2201;

NCBI Gene ID: 946710
Species: Escherichia coli strain K-12 substr. MG1655

The Ada N-terminal domain acts as a transcriptional activator of ada, alkA, alkB and aidB. [More information is available at EcoGene: EG10029]. O6-methylguanine and O4-methylthymine are the major mutagenic lesions resulting from exposure of DNA to simple alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), N-methyl-N-nitrosourea (MNU) and, to a lesser degree, methane methanesulfonate (MMS). [More information is available at EcoCyc: EG10029].

Gene sequence:
[Download sequence]

Proteins coded by this gene:

Authors Title Journal
Jeggo P Isolation and characterization of Escherichia coli K-12 mutants unable to induce the adaptive response to simple alkylating agents. J Bacteriol Sept. 1, 1979
Adhya S, Garges S Positive control. J Biol Chem July 5, 1990
Takano K, Nakamura T, Sekiguchi M Roles of two types of O6-methylguanine-DNA methyltransferases in DNA repair. Mutat Res Feb. 1, 1991
Shevell DE, Walker GC A region of the Ada DNA-repair protein required for the activation of ada transcription is not necessary for activation of alkA. Proc Natl Acad Sci U S A Oct. 15, 1991
Myers LC, Terranova MP, Nash HM, Markus MA, Verdine GL Zinc binding by the methylation signaling domain of the Escherichia coli Ada protein. Biochemistry May 19, 1992

Last modification of this entry: Oct. 6, 2010.

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