REPAIRtoire - a database of DNA repair pathways

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Bujnicki Lab Homepage

topA

Unnamed Gene ID: 945862

Known also as: asuA?; ECK1268; JW1266; supX;


NCBI Gene ID: 945862
Species: Escherichia coli strain K-12 substr. MG1655

Topoisomerase I is a type IA topoisomerase which is responsible for relaxing negative supercoils in DNA. [More information is available at EcoCyc: EG11013].


Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
Tse-Dinh YC Zinc (II) coordination in Escherichia coli DNA topoisomerase I is required for cleavable complex formation with DNA. J Biol Chem Aug. 5, 1991
Drlica K Control of bacterial DNA supercoiling. Mol Microbiol Jan. 1, 1992
Oram M, Fisher LM An Escherichia coli DNA topoisomerase I mutant has a compensatory mutation that alters two residues between functional domains of the DNA gyrase A protein. J Bacteriol June 1, 1992
Ishii S, Murakami T, Shishido K A pSC101-par sequence-mediated study on the intracellular state of supercoiling of the pBR322 genome in Escherichia coli DNA topoisomerase I deletion mutant. FEMS Microbiol Lett June 1, 1992
Mizushima T, Natori S, Sekimizu K Inhibition of Escherichia coli DNA topoisomerase I activity by phospholipids. Biochem J July 15, 1992

Last modification of this entry: Oct. 6, 2010.

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