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polA
Unnamed Gene ID: 948356
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Known also as: ECK3855; JW3835; resA;
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Residues 324-928 constitute the Klenow fragment. [More information is available at EcoGene: EG10746]. DNA Polymerase I (Pol I) is a multifunctional enzyme that combines a DNA polymerase activity, a 5' to 3' exonuclease activity and a 3' to 5' proofreading exonuclease activity. [More information is available at EcoCyc: EG10746].
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Gene sequence:
Proteins coded by this gene:
References:
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Authors
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Title
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Journal
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Billen D, Hellermann GR
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Role of deoxyribonucleic acid polymerases and deoxyribonucleic acid ligase in x-ray-induced repair synthesis in toluene-treated Escherichia coli K-12.
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J Bacteriol
May 1, 1976
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Murray NE, Kelley WS
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Characterization of lambdapolA transducing phages; effective expression of the E. coli polA gene.
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Mol Gen Genet
Aug. 1, 1979
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Beese LS, Steitz TA
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Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.
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EMBO J
Feb. 1, 1991
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Witkin EM, Roegner-Maniscalco V
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Overproduction of DnaE protein (alpha subunit of DNA polymerase III) restores viability in a conditionally inviable Escherichia coli strain deficient in DNA polymerase I.
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J Bacteriol
June 1, 1992
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Ruscitti T, Linn S
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DNA polymerase I modulates inducible stable DNA replication in Escherichia coli.
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J Bacteriol
Oct. 1, 1992
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Last modification of this entry: Oct. 6, 2010.
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