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"cDNA and structural organization of the gene Pole1 for the mouse DNA polymerase epsilon catalytic subunit." |
Huang D, Knuuti R, Palosaari H, Pospiech H, Syvaoja JE |
Published June 9, 1999 in Biochim Biophys Acta volume 1445 .
Pubmed ID: 10366722
Abstract:
| The cDNA and the gene for the mouse DNA polymerase epsilon catalytic subunit were cloned. The deduced protein sequence shows remarkable evolutionary conservation in DNA polymerase epsilon family. However, several conserved elements involved in template-primer binding differ from those of other class B polymerases. This is likely to reflect a distinctive function of the enzyme. The gene that was assigned to chromosome 5 region E3-E5, consists of 49 exons and has a non-conforming splice site in the junction of exon and intron 13. A CpG island covers the promoter region which contains several putative consensus elements critical for S phase upregulated and serum responsive promoters. |
This publication refers to following REPAIRtoire entries:
| Proteins |
Last modification of this entry: Oct. 6, 2010
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