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POLQ |
Protein FULL name:
DNA polymerase theta isoform 1 [Homo sapiens].
POLQ (Homo sapiens) is product of expression of POLQ gene.
POLQ is involved in:
TLS in Homo sapiens
Keywords:
FUNCTION: Could be involved in the repair of interstrand cross- links.
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SIMILARITY: Belongs to the DNA polymerase type-A family.
| NCBI GenPept GI number(s): |
40805845 |
| Species: | Homo sapiens |
Links to other databases:
| Database | ID | Link |
| Uniprot | O75417 |
O75417 |
| PFAM: | - |
O75417 (Link - using uniprot id) |
| InterPro: | - |
O75417 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MNGHRFTFRTRSLLPLQKGQHRCITKLLAHNDPWGIFRAPSSRRSYSVSG VCQPAIPNSSLHIPHNACWLKWKLCSEIALPYHHILGERRKLCSIRKFED WREDVRSCCQARVLPRGRTLGLWLALIGREEFAMNLLRRSGKRRRSESGS DSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERD KLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPT SAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIK VDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDE LHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSAT LPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPML QVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQ AEGEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAF HHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFG GRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPV RSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKE GKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLG SATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTID WYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAI HKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVF SNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGF HTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVT GRKGLTEREAAALIVEEARMILQQDLVEMGVQWNPCALLHSSTCSLTHSE SEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLNKSREH TSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKV VQTFSQKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRI HLQGQTLSNPSLCEDPFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFP LQIKQNCSWNITLTNDNFVEHIVTGSQSKNVTCQATSVVSEKGRGVAVEA EKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQSHEQTSTITKQKNIIE RQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDISRTVIP SEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVL CDFEDSFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMN SFQKECHIPFPAEQHPLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESP IFHSPILLEENGLFLKKNEVSVTDSQLNSFLQGYQTQETVKPVILLIPQK RTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLVKEQLPDMQMKEPLPS EVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSEMDSVQ MVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERA EKSKLTGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINF SSLNRKNTELNEEQEVISNLETKQVQGISFSSNNEVKSKIEMLENNANHD ETSSLLPRKESNIVDDNGLIPPTPIPTSASKLTFPGILETPVNPWKTNNV LQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPISDTSFSLQLSQDGLQL TPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIRSLTSS KTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYF SLQKEQKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIY DFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPH ELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSMNQLNSLLQ KENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLDAIET QAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGSTRRGI DNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQ REKCLNPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVG ESPPSQAVGKGLLPMGRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMR HAFVPFPGGSILAADYSQLELRILAHLSHDRRLIQVLNTGADVFRSIAAE WKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGEQMGIKENDAACYIDS FKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYRKAHAE RQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTG LSRKRKLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESA VKLSVKLKVKVKIGASWGELKDFDV |
POLQ (Homo sapiens) is able to recognize following damages:
References:
| Title | Authors | Journal |
| Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase. | Sharief FS, Vojta PJ, Ropp PA, Copeland WC | Genomics July 1, 1999 |
| Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis. | Wang B, Malik R, Nigg EA, Korner R | Anal Chem Dec. 15, 2008 |
| Lysine acetylation targets protein complexes and co-regulates major cellular functions. | Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M | Science Aug. 14, 2009 |
Last modification of this entry: Oct. 15, 2010.
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