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Protein FULL name:
NAD-dependent DNA ligase [Escherichia coli UTI89].
DNA ligase (Escherichia coli strain K-12 substr. MG1655) is product of expression of ligA gene.
DNA ligase is involved in:
MMR in Escherichia coli strain K-12 substr. MG1655
FUNCTION: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
CATALYTIC ACTIVITY: NAD(+) + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + nicotinamide nucleotide + (deoxyribonucleotide)(n+m).
SIMILARITY: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
SIMILARITY: Contains 1 BRCT domain.
Links to other databases:
Last modification of this entry: Oct. 19, 2010.
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