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Mfd |
Protein FULL name:
transcription-repair coupling factor [Escherichia coli str. K-12 substr. MG1655].
Mfd (Escherichia coli strain K-12 substr. MG1655) is product of expression of mfd gene.
Mfd is involved in:
NER in Escherichia coli strain K-12 substr. MG1655
Keywords:
FUNCTION: Necessary for strand-specific repair. A lesion in the template strand blocks the RNA polymerase complex (RNAP). The RNAP-DNA-RNA complex is specifically recognized by TRCF which releases RNAP and the truncated transcript; the TCRF may replace RNAP at the lesion site and then recruit the uvrA/B/C repair system.
INTERACTION: P0A8V2:rpoB; NbExp=2; IntAct=EBI-554211, EBI-544996;
SIMILARITY: In the N-terminal section; belongs to the uvrB family.
SIMILARITY: In the C-terminal section; belongs to the helicase family. RecG subfamily.
SIMILARITY: Contains 1 helicase ATP-binding domain.
SIMILARITY: Contains 1 helicase C-terminal domain.
| NCBI GenPept GI number(s): |
1787357 |
| Species: | Escherichia coli |
Links to other databases:
| Database | ID | Link |
| Uniprot | P30958 |
P30958 |
| PFAM: | - |
P30958 (Link - using uniprot id) |
| InterPro: | - |
P30958 (Link - using uniprot id) |
| CATH: | None | |
| SCOP: | None | |
| PDB: | - | - |
Protein sequence:
|
MPEQYRYTLPVKAGEQRLLGELTGAACATLVAEIAERHAGPVVLIAPDMQ NALRLHDEISQFTDQMVMNLADWETLPYDSFSPHQDIISSRLSTLYQLPT MQRGVLIVPVNTLMQRVCPHSFLHGHALVMKKGQRLSRDALRTQLDSAGY RHVDQVMEHGEYATRGALLDLFPMGSELPYRLDFFDDEIDSLRVFDVDSQ RTLEEVEAINLLPAHEFPTDKAAIELFRSQWRDTFEVKRDPEHIYQQVSK GTLPAGIEYWQPLFFSEPLPPLFSYFPANTLLVNTGDLETSAERFQADTL ARFENRGVDPMRPLLPPQSLWLRVDELFSELKNWPRVQLKTEHLPTKAAN ANLGFQKLPDLAVQAQQKAPLDALRKFLETFDGPVVFSVESEGRREALGE LLARIKIAPQRIMRLDEASDRGRYLMIGAAEHGFVDTVRNLALICESDLL GERVARRRQDSRRTINPDTLIRNLAELHIGQPVVHLEHGVGRYAGMTTLE AGGITGEYLMLTYANDAKLYVPVSSLHLISRYAGGAEENAPLHKLGGDAW SRARQKAAEKVRDVAAELLDIYAQRAAKEGFAFKHDREQYQLFCDSFPFE TTPDQAQAINAVLSDMCQPLAMDRLVCGDVGFGKTEVAMRAAFLAVDNHK QVAVLVPTTLLAQQHYDNFRDRFANWPVRIEMISRFRSAKEQTQILAEVA EGKIDILIGTHKLLQSDVKFKDLGLLIVDEEHRFGVRHKERIKAMRANVD ILTLTATPIPRTLNMAMSGMRDLSIIATPPARRLAVKTFVREYDSMVVRE AILREILRGGQVYYLYNDVENIQKAAERLAELVPEARIAIGHGQMREREL ERVMNDFHHQRFNVLVCTTIIETGIDIPTANTIIIERADHFGLAQLHQLR GRVGRSHHQAYAWLLTPHPKAMTTDAQKRLEAIASLEDLGAGFALATHDL EIRGAGELLGEEQSGSMETIGFSLYMELLENAVDALKAGREPSLEDLTSQ QTEVELRMPSLLPDDFIPDVNTRLSFYKRIASAKTENELEEIKVELIDRF GLLPDPARTLLDIARLRQQAQKLGIRKLEGNEKGGVIEFAEKNHVNPAWL IGLLQKQPQHYRLDGPTRLKFIQDLSERKTRIEWVRQFMRELEENAIA |
References:
| Title | Authors | Journal |
| Molecular mechanism of transcription-repair coupling. | Selby CP, Sancar A | Science April 2, 1993 |
| A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map. | Oshima T, Aiba H, Baba T, Fujita K, Hayashi K, Honjo A, Ikemoto K, Inada T, Itoh T, Kajihara M, Kanai K, Kashimoto K, Kimura S, Kitagawa M, Makino K, Masuda S, Miki T, Mizobuchi K, Mori H, Motomura K, Nakamura Y, Nashimoto H, Nishio Y, Saito N, Horiuchi T, et al. | DNA Res June 1, 1996 |
| The complete genome sequence of Escherichia coli K-12. | Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y | Science Sept. 5, 1997 |
| Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. | Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T | Mol Syst Biol Jan. 1, 2006 |
Last modification of this entry: Oct. 19, 2010.
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