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Rad2p |
Rad2p is involved in:
NER in Saccharomyces cerevisiae
- Rad2 joins the complex in Saccharomyces cerevisiae
- recruitment of Rad1/Rad10 complex in Saccharomyces cerevisiae
- RNAP dissociates in Saccharomyces cerevisiae
- ubiquitination of Rad26 in Saccharomyces cerevisiae
- Removal of the damaged strand fragment in Saccharomyces cerevisiae
- removal of fragment of damaged strand in Saccharomyces cerevisiae
- Rad14 recruits Rad1/Rad10 complex in Saccharomyces cerevisiae
- XPC complex dissotiates in Saccharomyces cerevisiae
FUNCTION: Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross- linking agents. Essential for the incision step of excision- repair.
COFACTOR: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding (By similarity).
INTERACTION: Q08215:PEX15; NbExp=1; IntAct=EBI-14757, EBI-31849;
SUBCELLULAR LOCATION: Nucleus.
MISCELLANEOUS: Present with 846 molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
| NCBI GenPept GI number(s): |
6321697 |
| Species: | Saccharomyces cerevisiae |
Links to other databases:
| Database | ID | Link |
| Uniprot | P07276 |
P07276 |
| PFAM: | - |
P07276 (Link - using uniprot id) |
| InterPro: | - |
P07276 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
MGVHSFWDIAGPTARPVRLESLEDKRMAVDASIWIYQFLKAVRDQEGNAV KNSHITGFFRRICKLLYFGIRPVFVFDGGVPVLKRETIRQRKERRQGKRE SAKSTARKLLALQLQNGSNDNVKNSTPSSGSSVQIFKPQDEWDLPDIPGF KYDKEDARVNSNKTFEKLMNSINGDGLEDIDLDTINPASAEFEELPKATQ YLILSSLRLKSRLRMGYSKEQLETIFPNSMDFSRFQIDMVKRRNFFTQKL INTTGFQDGGASKLNEEVINRISGQKSKEYKLTKTNNGWILGLGANDGSD AQKAIVIDDKDAGALVKQLDSNAEDGDVLRWDDLEDNSLKIVRHESSNAT TAPQKRSNRSEDEGCDSDECEWEEVELKPKNVKFVEDFSLKAARLPYMGQ SLNNAGSKSFLDKRHDQASPSKTTPTMRISRISVEDDDEDYLKQIEEIEM MEAVQLSKMEKKPEADDKSKIAKPVTSKGTEARPPIVQYGLLGAQPDSKQ PYHVTNLNSKSESVIKRTSKTVLSEFRPPSQQEDKGAILTEGEQNLNFIS HKIPQFDFNNENSLLFQKNTESNVSQEATKEKSPIPEMPSWFSSTASQQL YNPYNTTNFVEDKNVRNEQESGAETTNKGSSYELLTGLNATEILERESEK ESSNDENKDDDLEVLSEELFEDVPTKSQISKEAEDNDSRKVESINKEHRK PLIFDYDFSEDEEDNIVENMIKEQEEFDTFKNTTLSTSAERNVAENAFVE DELFEQQMKDKRDSDEVTMDMIKEVQELLSRFGIPYITAPMEAEAQCAEL LQLNLVDGIITDDSDVFLFGGTKIYKNMFHEKNYVEFYDAESILKLLGLD RKNMIELAQLLGSDYTNGLKGMGPVSSIEVIAEFGNLKNFKDWYNNGQFD KRKQETENKFEKDLRKKLVNNEIILDDDFPSVMVYDAYMRPEVDHDTTPF VWGVPDLDMLRSFMKTQLGWPHEKSDEILIPLIRDVNKRKKKGKQKRINE FFPREYISGDKKLNTSKRISTATGKLKKRKM |
References:
| Title | Authors | Journal |
| The RAD2 gene of Saccharomyces cerevisiae: nucleotide sequence and transcript mapping. | Nicolet CM, Chenevert JM, Friedberg EC | Gene Jan. 1, 1985 |
| Nucleotide sequence, transcript mapping, and regulation of the RAD2 gene of Saccharomyces cerevisiae. | Madura K, Prakash S | J Bacteriol June 1, 1986 |
| Yeast excision repair gene RAD2 encodes a single-stranded DNA endonuclease. | Habraken Y, Sung P, Prakash L, Prakash S | Nature Nov. 25, 1993 |
| Analysis of an 11.6 kb region from the right arm of chromosome VII of Saccharomyces cerevisiae between the RAD2 and the MES1 genes reveals the presence of three new genes. | Clemente ML, Sartori G, Cardazzo B, Carignani G | Yeast March 15, 1997 |
| The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. | Tettelin H, Agostoni Carbone ML, Albermann K, Albers M, Arroyo J, Backes U, Barreiros T, Bertani I, Bjourson AJ, Bruckner M, Bruschi CV, Carignani G, Castagnoli L, Cerdan E, Clemente ML, Coblenz A, Coglievina M, Coissac E, Defoor E, Del Bino S, Delius H, Delneri D, de Wergifosse P, Dujon B, Kleine K, et al. | Nature May 1, 1997 |
| Global analysis of protein expression in yeast. | Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS | Nature Oct. 16, 2003 |
| A multidimensional chromatography technology for in-depth phosphoproteome analysis. | Albuquerque CP, Smolka MB, Payne SH, Bafna V, Eng J, Zhou H | Mol Cell Proteomics July 1, 2008 |
Last modification of this entry: Oct. 6, 2010.
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