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Topoisomerase I (sub omega) |
Protein FULL name:
unnamed protein product [Escherichia coli].
Topoisomerase I (sub omega) (Escherichia coli strain K-12 substr. MG1655) is product of expression of topA gene.
FUNCTION: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another.
CATALYTIC ACTIVITY: ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
SUBUNIT: Monomer.
INTERACTION: P27862:yigZ; NbExp=1; IntAct=EBI-544172, EBI-561235;
MISCELLANEOUS: When a topoisomerase transiently breaks a DNA backbone bond, it simultaneously forms a protein-DNA link, in which a tyrosyl oxygen in the enzyme is joined to a DNA phosphorus at one end of the enzyme-severed DNA strand.
SIMILARITY: Belongs to the prokaryotic type I/III topoisomerase family.
SIMILARITY: Contains 1 Toprim domain.
| NCBI GenPept GI number(s): |
415338 |
| Species: | Escherichia coli |
Links to other databases:
| Database | ID | Link |
| Uniprot | P06612 |
P06612 |
| PFAM: | - |
P06612 (Link - using uniprot id) |
| InterPro: |
IPR000380 IPR003601 IPR003602 IPR005733 IPR006154 IPR006171 IPR013263 IPR013497 IPR013498 IPR013824 |
IPR000380 IPR003601 IPR003602 IPR005733 IPR006154 IPR006171 IPR013263 IPR013497 IPR013498 IPR013824 |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | 1CY0 1CY1 1CY2 1CY4 1CY6 1CY7 1CY8 1CY9 1CYY 1ECL 1MW8 1MW9 1YUA |
1CY0 1CY1 1CY2 1CY4 1CY6 1CY7 1CY8 1CY9 1CYY 1ECL 1MW8 1MW9 1YUA |
Protein sequence:
|
MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADS TSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA EKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQA FNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVA VRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVN KEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE SPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVA CQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRIL PAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASI ISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSL DQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCP TCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGED AETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFR IKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAP PKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEEL YRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATG WSAFYVDGKWVEGKK |
Topoisomerase I (sub omega) (Escherichia coli strain K-12 substr. MG1655) is able to recognize following damages:
Solved crystal structures:
References:
| Title | Authors | Journal |
| Complete nucleotide sequence of the topA gene encoding Escherichia coli DNA topoisomerase I. | Tse-Dinh YC, Wang JC | J Mol Biol Oct. 5, 1986 |
| DNA sequences of the cysB regions of Salmonella typhimurium and Escherichia coli. | Ostrowski J, Jagura-Burdzy G, Kredich NM | J Biol Chem May 5, 1987 |
| Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I. | Lima CD, Wang JC, Mondragon A | Nature Feb. 13, 1994 |
| Solution structure of the C-terminal single-stranded DNA-binding domain of Escherichia coli topoisomerase I. | Yu L, Zhu CX, Tse-Dinh YC, Fesik SW | Biochemistry June 13, 1995 |
| A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map. | Aiba H, Baba T, Hayashi K, Inada T, Isono K, Itoh T, Kasai H, Kashimoto K, Kimura S, Kitakawa M, Kitagawa M, Makino K, Miki T, Mizobuchi K, Mori H, Mori T, Motomura K, Nakade S, Nakamura Y, Nashimoto H, Nishio Y, Oshima T, Saito N, Sampei G, Horiuchi T, et al. | DNA Res Dec. 31, 1996 |
| The complete genome sequence of Escherichia coli K-12. | Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y | Science Sept. 5, 1997 |
| Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. | Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T | Mol Syst Biol Jan. 1, 2006 |
Last modification of this entry: Oct. 6, 2010.
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