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About Laboratory Of Bioinformatics And Protein Engineering

Our group is involved in theoretical and experimental research on nucleic acids and proteins. The current focus is on RNA sequence-structure-function relationships (in particular 3D modeling), RNA-protein complexes, and enzymes acting on RNA.
 
We study the rules that govern the sequence-structure-function relationships in proteins and nucleic acids and use the acquired knowledge to predict structures and functions for uncharacterized gene products, to alter the known structures and functions of proteins and RNAs and to engineer molecules with new properties.
 
Our key strength is in the integration of various types of theoretical and experimental analyses. We develop and use computer programs for modeling of protein three-dimensional structures based on heterogenous, low-resolution, noisy and ambivalent experimental data. We are also involved in genome-scale phylogenetic analyses, with the focus on identification of proteins that belong to particular families. Subsequently, we characterize experimentally the function of the most interesting new genes/proteins identified by bioinformatics. We also use theoretical predictions to guide protein engineering, using rational and random approaches. Our ultimate goal is to identify complete sets of enzymes involved in particular metabolic pathways (e.g. RNA modification, DNA repair) and to design proteins with new properties, in particular enzymes with new useful functions, which have not been observed in the nature.
 
We are well-equipped with respect to both theoretical and experimental analyses. Our lab offers excellent environment for training of young researchers in both bioinformatics and molecular biology/biochemistry of protein-nucleic acid interactions.


More Good Science

Adam Mickiewicz University in Poznań (AMU)

and International Institute of Molecular and Cell Biology in Warsaw (IIMCB)


invite applications for Research Group Leader in Bioinformatics

 

We seek a talented and dynamic scientist early in his/her career to establish a joint AMU & IIMCB research group located at the Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University (IBMIB-AMU) in Poznań, Poland.

IIMCB and Faculty of Biology AMU to which IBMIB-AMU belongs are among Poland's top-ranked academic institutions in the field of biology, working together based on a bilateral agreement. Research topics at both institutes cover a wide spectrum of molecular and cellular biology, biotechnology, structural and computational biology. Both institutes are involved in various national and international research projects and provide cutting-edge equipment and facilities for wet-lab work and bioinformatics. IBMIB-AMU, where the group will be located, is situated at a modern academic Morasko campus in Poznań and provides outstanding research opportunities for their scientists in a stimulating environment.

For the Research Group Leader position we will consider candidates with a strong scientific track record in bioinformatics and clear evidence of leadership as well as an ability to attract extramural funding. The successful candidate will be expected to develop an independent research program in bioinformatics to complement research activities in IBMIB-AMU and IIMCB, and will be responsible for teaching a course in bioinformatics and training of young scientists within the framework of MSc and PhD studies at AMU.

The startup package includes the salary of the group leader, two PhD student positions, start-up funding, furnished laboratory and office space at IBMIB-AMU and access to all shared equipment of both institutions. The initial contract will be for 5 years, with a possible extension dependent on the results of periodic evaluation(s). The position is open from October 1, 2015 however the starting date is negotiable.

Deadline for application is June 30, 2015. Applications should be submitted by email to rekrutacja@iimcb.gov.pl

 

Applications should include:

  • a cover letter explaining reasons for application,
  • a Curriculum Vitae including a list of publications,
  • statement of scientific achievements (up to 1 page),
  • a summary of the applicant's future research plans (2 pages) including potential for prospective collaboration with particular groups at IBMIB-AMU and IIMCB,
  • addresses of two academic reference persons,
  • copies of three most important papers,

 one page description of candidate's experience in teaching and a summary of proposed MSc and PhD-level courses in bioinformatics

 

The application must contain the following statement: "In accordance with the personal data protection act from 29th August 1997, I hereby agree to process and to store my personal data by the Institution for recruitment purposes".