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Rad27p |
Protein FULL name:
5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family
Protein SHORT name:
ERC11, FEN1, RTH1
Rad27p (Saccharomyces cerevisiae) is product of expression of RAD27 gene.
Rad27p is involved in:
NHEJ in Saccharomyces cerevisiae BER in Saccharomyces cerevisiae
- Gap filling and strand displacement with DPB3 in Saccharomyces cerevisiae
- Strand scission by APN1/APN2/Pol30/Rad27/Pol3/CDC9 complex in Saccharomyces cerevisiae
- Gap filling and strand displacement with Pol3 in Saccharomyces cerevisiae
- Strand scission by APN1/APN2/Pol30/Rad27/DPB3/CDC9 complex in Saccharomyces cerevisiae
- Removing overhang by complex with Pol3 in Saccharomyces cerevisiae
- Removing overhang by complex with DPB3 in Saccharomyces cerevisiae
FUNCTION: Single-stranded DNA endonuclease (Probable).
COFACTOR: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding (By similarity).
INTERACTION: P38859:DNA2; NbExp=1; IntAct=EBI-14693, EBI-5973; P47135:JSN1; NbExp=1; IntAct=EBI-14693, EBI-9422; P15873:POL30; NbExp=1; IntAct=EBI-14693, EBI-12993;
SUBCELLULAR LOCATION: Nucleus (Probable).
MISCELLANEOUS: Present with 6120 molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
| NCBI GenPept GI number(s): |
6322736 |
| Species: | Saccharomyces cerevisiae |
Links to other databases:
| Database | ID | Link |
| Uniprot | P26793 |
P26793 |
| PFAM: | - |
P26793 (Link - using uniprot id) |
| InterPro: | - |
P26793 (Link - using uniprot id) |
| CATH: | None | |
| SCOP: | None | |
| PDB: | - | - |
Protein sequence:
|
MGIKGLNAIISEHVPSAIRKSDIKSFFGRKVAIDASMSLYQFLIAVRQQD GGQLTNEAGETTSHLMGMFYRTLRMIDNGIKPCYVFDGKPPDLKSHELTK RSSRRVETEKKLAEATTELEKMKQERRLVKVSKEHNEEAQKLLGLMGIPY IIAPTEAEAQCAELAKKGKVYAAASEDMDTLCYRTPFLLRHLTFSEAKKE PIHEIDTELVLRGLDLTIEQFVDLCIMLGCDYCESIRGVGPVTALKLIKT HGSIEKIVEFIESGESNNTKWKIPEDWPYKQARMLFLDPEVIDGNEINLK WSPPKEKELIEYLCDDKKFSEERVKSGISRLKKGLKSGIQGRLDGFFQVV PKTKEQLAAAAKRAQENKKLNKNKNKVTKGRR |
Rad27p (Saccharomyces cerevisiae) belongs to following protein families:
References:
Last modification of this entry: Oct. 6, 2010.
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