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Bujnicki Lab Homepage

DRR in Homo sapiens

direct reversal repair

(also known as direct DNA damage reversal)

Proteins:
ALKBH2
ALKBH3
MGMT

DRR in REACTOME: 73942



Cells are known to eliminate three types of damage to their DNA by chemically reversing it. These mechanisms do not require a template, since the types of damage they counteract can only occur in one of the four bases. Such direct reversal mechanisms are specific to the type of damage incurred and do not involve breakage of the phosphodiester backbone. Methylation of guanine bases, is directly reversed by the protein methyl guanine methyl transferase (MGMT), the bacterial equivalent of which is called Ogt. This is an expensive process because each MGMT molecule can only be used once; that is, the reaction is stoichiometric rather than catalytic. A generalized response to methylating agents in bacteria is known as the adaptive response and confers a level of resistance to alkylating agents upon sustained exposure by upregulation of alkylation repair enzymes. The next type of DNA damage reversed by cells is certain methylation of the bases cytosine and adenine by ALKBH2 and ALKBH3.

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