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Mismatch in heteroduplex DNA with nick 5' to mismatch and nicks around mismatch bound by MutSalpha-MutLalpha complex

[Homo sapiens]





Note that
  • Although in this figure MutSalpha-MutLalpha complex is still located at the mismatch site after introducing the nicks, most likely the MutSalpha-MutLalpha leaves the mismatch site before introducing the nick, probably by sliding movement. This issue, however, is not resolved yet.
  • Physical interactions between PCNA and MutSalpha-MutLalpha complex may take place at this step. Such interactions may help to direct DNA nicking to the daughter strand.

Mismatch in heteroduplex DNA with nick 5' to mismatch and nicks around mismatch bound by MutSalpha-MutLalpha complex is part of following pathways: This DNA state is a resulting state in the following reactions:

Reaction Previous state Following state
MutLalpha nicks heteroduplex DNA with nick 5' to mismatch in Homo sapiens Mismatch in heteroduplex DNA with nick 5' to mismatch bound by MutSalpha-MutLalpha complex in Homo sapiens Mismatch in heteroduplex DNA with nick 5' to mismatch and nicks around mismatch bound by MutSalpha-MutLalpha complex in Homo sapiens

This DNA state is a previous state in the following reactions:

Reaction Previous state Following state
ExoI loads onto heteroduplex DNA with nick 5' to mismatch (distant site) in Homo sapiens Mismatch in heteroduplex DNA with nick 5' to mismatch and nicks around mismatch bound by MutSalpha-MutLalpha complex in Homo sapiens Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex, bound by ExoI (distant site) in Homo sapiens
ExoI loads onto heteroduplex DNA with nick 5' to mismatch (on proximal site) in Homo sapiens Mismatch in heteroduplex DNA with nick 5' to mismatch and nicks around mismatch bound by MutSalpha-MutLalpha complex in Homo sapiens Heteroduplex DNA with nick 5' to mismatch and nicks around mismatch, and with bound MutSalpha-MutLalpha complex, bound by ExoI (proximal site) in Homo sapiens

References:

Authors Title Journal
Kadyrov FA, Dzantiev L, Constantin N, Modrich P Endonucleolytic function of MutLalpha in human mismatch repair.
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Masih PJ, Kunnev D, Melendy T Mismatch Repair proteins are recruited to replicating DNA through interaction with Proliferating Cell Nuclear Antigen (PCNA).
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