REPAIRtoire - a database of DNA repair pathways

Welcome! Click here to login or here to register.
Home
Proteins
DNA damage
Diseases
Homologs
Pathways
Keywords
Publications
Draw a picture
 
Search
 
Links
Help
Contact





Bujnicki Lab Homepage

Wrn

Werner syndrome homolog (human)

On chromosome: 8 20.0 cM
Known also as: AI846146;


NCBI Gene ID: 22427
NCBI Ensembl Id: ENSMUSG00000031583
Species: Mus musculus

Mus musculus Werner syndrome homolog (human) (Wrn), transcript variant 1.


Gene sequence:
[Download sequence]

Proteins coded by this gene:
References:

Authors Title Journal
Lebel M, Leder P A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci U S A Oct. 27, 1998
Huang S, Beresten S, Li B, Oshima J, Ellis NA, Campisi J Characterization of the human and mouse WRN 3'-->5' exonuclease. Nucleic Acids Res June 15, 2000
Kawabe Yi, Branzei D, Hayashi T, Suzuki H, Masuko T, Onoda F, Heo SJ, Ikeda H, Shimamoto A, Furuichi Y, Seki M, Enomoto T A novel protein interacts with the Werner's syndrome gene product physically and functionally. J Biol Chem June 8, 2001
Lebel M, Lavoie J, Gaudreault I, Bronsard M, Drouin R Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice. Am J Pathol May 1, 2003
Chang S, Multani AS, Cabrera NG, Naylor ML, Laud P, Lombard D, Pathak S, Guarente L, DePinho RA Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet Aug. 1, 2004

Last modification of this entry: Oct. 6, 2010.

Add your own comment!

There is no comment yet.
Welcome stranger! Click here to login or here to register.
Valid HTML 4.01! This site is Emacs powered. Made with Django.