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Wrn |
Protein FULL name:
Werner syndrome ATP-dependent helicase homolog [Mus musculus].
Wrn (Mus musculus) is product of expression of Wrn gene.
FUNCTION: Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA- helicase activity. May be involved in the control of genomic stability.
CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
SUBUNIT: Interacts with EXO1 (By similarity). Interacts via its N- terminal domain with WRNIP1.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed ubiquitously in most organs at a low level, highly expressed in testis, ovary and spleen.
PTM: Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity).
SIMILARITY: Belongs to the helicase family. RecQ subfamily.
SIMILARITY: Contains 1 3'-5' exonuclease domain.
SIMILARITY: Contains 1 helicase ATP-binding domain.
SIMILARITY: Contains 1 helicase C-terminal domain.
SIMILARITY: Contains 1 HRDC domain.
| NCBI GenPept GI number(s): |
170763502 |
| Species: | Mus musculus |
Links to other databases:
| Database | ID | Link |
| Uniprot | O09053 |
O09053 |
| PFAM: | - |
O09053 (Link - using uniprot id) |
| InterPro: | - |
O09053 (Link - using uniprot id) |
| CATH: | - | - |
| SCOP: | - | - |
| PDB: | - | - |
Protein sequence:
|
METTSLQRKFPEWMSMQSQRCATEEKACVQKSVLEDNLPFLEFPGSIVYS YEASDCSFLSEDISMRLSDGDVVGFDMEWPPIYKPGKRSRVAVIQLCVSE SKCYLFHISSMSVFPQGLKMLLENKSIKKAGVGIEGDQWKLLRDFDVKLE SFVELTDVANEKLKCAETWSLNGLVKHVLGKQLLKDKSIRCSNWSNFPLT EDQKLYAATDAYAGLIIYQKLGNLGDTAQVFALNKAEENLPLEMKKQLNS ISEEMRDLANRFPVTCRNLETLQRVPVILKSISENLCSLRKVICGPTNTE TRLKPGSSFNLLSSEDSAAAGEKEKQIGKHSTFAKIKEEPWDPELDSLVK QEEVDVFRNQVKQEKGESENEIEDNLLREDMERTCVIPSISENELQDLEQ QAKEEKYNDVSHQLSEHLSPNDDENDSSYIIESDEDLEMEMLKSLENLNS DVVEPTHSTWLEMGTNGRLPPEEEDGHGNEAIKEEQEEEDHLLPEPNAKQ INCLKTYFGHSSFKPVQWKVIHSVLEERRDNVVVMATGYGKSLCFQYPPV YTGKIGIVISPLISLMEDQVLQLELSNVPACLLGSAQSKNILGDVKLGKY RVIYITPEFCSGNLDLLQQLDSSIGITLIAVDEAHCISEWGHDFRSSFRM LGSLKTALPLVPVIALSATASSSIREDIISCLNLKDPQITCTGFDRPNLY LEVGRKTGNILQDLKPFLVRKASSAWEFEGPTIIYCPSRKMTEQVTAELG KLNLACRTYHAGMKISERKDVHHRFLRDEIQCVVATVAFGMGINKADIRK VIHYGAPKEMESYYQEIGRAGRDGLQSSCHLLWAPADFNTSRNLLIEIHD EKFRLYKLKMMVKMEKYLHSSQCRRRIILSHFEDKCLQKASLDIMGTEKC CDNCRPRLNHCLTANNSEDASQDFGPQAFQLLSAVDILQEKFGIGIPILF LRGSNSQRLPDKYRGHRLFGAGKEQAESWWKTLSHHLIAEGFLVEVPKEN KYIKTCSLTKKGRKWLGEASSQSPPSLLLQANEEMFPRKVLLPSSNPVSP ETTQHSSNQNPAGLTTKQSNLERTHSYKVPEKVSSGTNIPKKSAVMPSPG TSSSPLEPAISAQELDARTGLYARLVEARQKHANKMDVPPAILATNKVLL DMAKMRPTTVENMKQIDGVSEGKAALLAPLLEVIKHFCQVTSVQTDLLSS AKPHKEQEKSQEMEKKDCSLPQSVAVTYTLFQEKKMPLHSIAENRLLPLT AAGMHLAQAVKAGYPLDMERAGLTPETWKIIMDVIRNPPINSDMYKVKLI RMLVPENLDTYLIHMAIEILQSGSDSRTQPPCDSSRKRRFPSSAESCESC KESKEAVTETKASSSESKRKLPEWFAKGNVPSADTGSSSSMAKTKKKGLF S |
Wrn (Mus musculus) belongs to following protein families:
References:
| Title | Authors | Journal |
| Cloning of a mouse homologue of the human Werner syndrome gene and assignment to 8A4 by fluorescence in situ hybridization. | Imamura O, Ichikawa K, Yamabe Y, Goto M, Sugawara M, Furuichi Y | Genomics April 15, 1997 |
| Nucleolar localization of the Werner syndrome protein in human cells. | Marciniak RA, Lombard DB, Johnson FB, Guarente L | Proc Natl Acad Sci U S A June 9, 1998 |
| Mutations in the WRN gene in mice accelerate mortality in a p53-null background. | Lombard DB, Beard C, Johnson B, Marciniak RA, Dausman J, Bronson R, Buhlmann JE, Lipman R, Curry R, Sharpe A, Jaenisch R, Guarente L | Mol Cell Biol May 1, 2000 |
| A novel protein interacts with the Werner's syndrome gene product physically and functionally. | Kawabe Yi, Branzei D, Hayashi T, Suzuki H, Masuko T, Onoda F, Heo SJ, Ikeda H, Shimamoto A, Furuichi Y, Seki M, Enomoto T | J Biol Chem June 8, 2001 |
Last modification of this entry: Oct. 6, 2010.
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