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Wrn
Werner syndrome homolog (human)
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On chromosome: 8 20.0 cM
Known also as: AI846146;
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Mus musculus Werner syndrome homolog (human) (Wrn), transcript variant 1.
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Gene sequence:
Proteins coded by this gene:
References:
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Authors
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Title
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Journal
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Lebel M, Leder P
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A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity.
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Proc Natl Acad Sci U S A
Oct. 27, 1998
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Huang S, Beresten S, Li B, Oshima J, Ellis NA, Campisi J
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Characterization of the human and mouse WRN 3'-->5' exonuclease.
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Nucleic Acids Res
June 15, 2000
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Kawabe Yi, Branzei D, Hayashi T, Suzuki H, Masuko T, Onoda F, Heo SJ, Ikeda H, Shimamoto A, Furuichi Y, Seki M, Enomoto T
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A novel protein interacts with the Werner's syndrome gene product physically and functionally.
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J Biol Chem
June 8, 2001
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Lebel M, Lavoie J, Gaudreault I, Bronsard M, Drouin R
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Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice.
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Am J Pathol
May 1, 2003
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Chang S, Multani AS, Cabrera NG, Naylor ML, Laud P, Lombard D, Pathak S, Guarente L, DePinho RA
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Essential role of limiting telomeres in the pathogenesis of Werner syndrome.
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Nat Genet
Aug. 1, 2004
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Last modification of this entry: Oct. 6, 2010.
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