REPAIRtoire - a database of DNA repair pathways

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Keyword: direct reversal repair (DRR)

Direct reversal repair (direct repair of DNA) is a single step reaction of removal of the methyl- or photoadduct.
1. Methylphosphotriesters - direct removal of the alkyl damage by nucleophilic Cys residues.
Direct repair O6-alkylguanine by Ada (E.coli)
2. DNA Alkyltransferases
Direct repair of O6-alkylguanine by MGMT (H.sapiens)
Direct repair of O4-Alkylthymine by Ogt (E.coli)
3. Oxidative dealkylation
AlkB proteins (E.coli, H.sapiens)
4. Photolyase - direct reversal of the thymine dimer created by UV light
CTD photolyase (E.coli, S.cerevisiae)
(6-4)TT photolysae

REPAIRtoire objects related to the direct reversal repair (DRR) keyword:

Category name	Results
DNA damages	6-4PP CPD O6-alkylG pyrimidine dimer thymidine dimer 1,N6-ethenoA 3,N4-ethenoC 1,N2-ethenoG 1mA 1mG 3mC 3mT
Proteins	ALKBH2 (Homo sapiens) ALKBH3 (Homo sapiens) AlkB (Escherichia coli strain K-12 substr. MG1655) MGMT (Homo sapiens) Phr (Escherichia coli strain K-12 substr. MG1655) Phr1p (Saccharomyces cerevisiae) Ada (Escherichia coli strain K-12 substr. MG1655) Ogt (Escherichia coli strain K-12 substr. MG1655)
Damage sources	UV radiation alkylating agents chloroacetaldehyde
Pathways	DRR in Homo sapiens DRR in Escherichia coli strain K-12 substr. MG1655

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