Welcome! Click here to login or here to register.
Home
Proteins
DNA damage
Diseases
Homologs
Pathways
Keywords
Publications
Draw a picture
 
Search
 
Links
Help
Contact





Bujnicki Lab Homepage

MMR in Saccharomyces cerevisiae

mismatch repair

Proteins:
Cdc9p
Dpb2p
Dpb3p
Exo1p
Mlh1p
Msh2p
Msh3p
Msh6p
Pol delta
Pol epsilon
Pol30p
Pol3p
Rfc5p
Rpa1p

MMR in KEGG: sce03430
[picture] [information]



DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.

Keywords:

alt alt alt alt alt alt alt alt alt alt alt alt alt alt alt alt alt alt alt alt alt alt alt alt
Add your own comment!

There is no comment yet.
Welcome stranger! Click here to login or here to register.
Valid HTML 4.01! This site is Emacs powered. Made with Django.